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| Status |
Public on Sep 01, 2011 |
| Title |
Expression data from Thymocytes of WT, TCF-1-deficient and β-catenin transgenic mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Both TCF-1 and its coactivator β-catenin are known to be required for supporting normal double positive (DP) thymocyte survival through upregulating Bcl-xL. However, the downstream factors mediating this effect remained unknown.
We used microarray to compare the global expression difference among WT, TCF-1-deficient, and β-catenin transgenic thymocytes to search for the genes that are down-regulated and up-regulated in TCF-1-deficient and β-catenin transgenic thymocytes, respectively.
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| Overall design |
We focus on the genes that are significantly down-regulated and up-regulated in TCF-1-deficient and β-catenin transgenic thymocytes, respectively, to select for those genes that are potential target genes of β-catenin/TCF-1 pathway. And then those genes are subject to IPA pathway analysis searching for genes that are involved in thymocyte development and cell death.
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| Contributor(s) |
Wang R |
| Citation(s) |
22039299 |
| Submission date |
Aug 14, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
ruiqing wang |
| E-mail(s) |
rwang@coh.org
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| Organization name |
city of hope
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| Street address |
1500 duarte rd
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| City |
duarte |
| State/province |
ca |
| ZIP/Postal code |
91010 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA145897 |
