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| Status |
Public on Dec 31, 2011 |
| Title |
Establishing a set of genes differentially expressed in benign versus malignant adrenocortical cells |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by array
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| Summary |
Models for tumorigenesis can be made by transforming normal cells with defined genetic elements. This allows us to determine that adrenocortical tumor development and progression follows a multistep model. Morever, we demonstrated that the order of genetic events has a great consequence on the phenotype of the resultant tumor. We performed transcriptomic analysis using cDNA microarrays to identify the molecular signature that might explain the distinctive in vivo phenotypes observed in response to both orders of the mutational events.
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| Overall design |
Two p53+Ras two pBabe +pLNCX2 (control for the p53+Ras cells), three Ras+p53 and two pLNCX2+pBabe (control for Ras+p53 cells) cell populations were prepared and used for microarray analysis;
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| Citation(s) |
22589739 |
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| Submission date |
Sep 22, 2011 |
| Last update date |
Dec 17, 2012 |
| Contact name |
Michaël Thomas |
| E-mail(s) |
michael.thomas@cea.fr
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| Phone |
(33)-438-78-44-64
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| Fax |
(33)-438-78-50-58
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| Organization name |
Inserm U1036
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| Department |
iRTSV/BCI
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| Street address |
17 rue des martyrs
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| City |
Grenoble |
| ZIP/Postal code |
38054 |
| Country |
France |
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| Platforms (1) |
| GPL2112 |
[Bovine] Affymetrix Bovine Genome Array |
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| Samples (9)
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| GSM800430 |
Bovine adrenocortical cells transduced with p53 and Ras, biological rep1 |
| GSM800431 |
Bovine adrenocortical cells transduced with p53 and Ras, biological rep2 |
| GSM800432 |
Bovine adrenocortical cells transduced with Ras and p53, biological rep1 |
| GSM800433 |
Bovine adrenocortical cells transduced with Ras and p53, biological rep2 |
| GSM800434 |
Bovine adrenocortical cells transduced with Ras and p53, biological rep3 |
| GSM800435 |
Bovine adrenocortical cells transduced with pLNCX2 and pBabe, biological rep1 |
| GSM800436 |
Bovine adrenocortical cells transduced with pLNCX2 and pBabe, biological rep2 |
| GSM800437 |
Bovine adrenocortical cells transduced with pBabe and pLNCX2, biological rep1 |
| GSM800438 |
Bovine adrenocortical cells transduced with pBabe and pLNCX2, biological rep2 |
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| Relations |
| BioProject |
PRJNA146345 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32305_RAW.tar |
20.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| GSE32305_fold_change.txt.gz |
179.5 Kb |
(ftp)(http) |
TXT |
| Processed data provided as supplementary file |
| Processed data included within Sample table |
| Processed data are available on Series record |
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