|
| Status |
Public on Dec 27, 2011 |
| Title |
Expression data from Ezh2-null erythrocyte/megakaryocyte progenitor (MEP) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through transcriptional repression of target genes. EZH2 is a catalytic component of PRC2 and trimethylates histone H3 at lysine 27 to transcriptionally repress the target genes. PcG proteins have been characterized as general regulators of stem cells, but recent works also unveiled their critical roles in cancer.
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| |
|
| Overall design |
Wild type and Ezh2 null MEP from fetal liver and adult bone marrow
|
| |
|
| Contributor(s) |
Iwama A, Mochizuki-Kashio M |
| Citation(s) |
22042701 |
| |
| Submission date |
Oct 12, 2011 |
| Last update date |
Jan 19, 2018 |
| Contact name |
ATSUSHI IWAMA |
| E-mail(s) |
aiwama@faculty.chiba-u.jp
|
| Phone |
81-43-226-2187
|
| Fax |
81-43-226-2191
|
| Organization name |
Graduate School of Medicine, Chiba University
|
| Department |
Department of Cellular and Molecular Medicine
|
| Street address |
1-8-1 Inohana, Chuo-ku
|
| City |
Chiba |
| ZIP/Postal code |
260-8670 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL10333 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA146497 |
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