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| Status |
Public on Dec 31, 2011 |
| Title |
miRNA expression profile in leprosy skin biopsy specimens |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Skin biopsy specimens of skin lesions were profiled for miRNA expression.
In this study, we indentified miRNA species that were differentially expressed in the skin lesions of either the lepromatous or tuberculoid forms of leprosy. One miRNA species, hsa-mir-21, found in the lepromatous lesions was capable of downregulating the vitamin D-dependent antimicrobial pathway.
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| Overall design |
Scalpel or punch skin biopsy specimens were obtained after informed consent from patients with tuberculoid leprosy and patients with lepromatous leprosy at the time of diagnosis. Specimens were embedded in OCT medium, snap-frozen in liquid nitrogen and stored at 80°C until sectioning.
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| Contributor(s) |
Liu PT, Modlin RL |
| Citation(s) |
22286305 |
| Submission date |
Oct 24, 2011 |
| Last update date |
Apr 02, 2012 |
| Contact name |
Philip T. Liu |
| E-mail(s) |
ptliu@mednet.ucla.edu
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| Phone |
310-206-8457
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| Organization name |
University of California at Los Angeles
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| Department |
Department of Orthopaedic Surgery
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| Lab |
Liu Lab
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| Street address |
615 Charles E Young Drive South, 410 OHRC
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL14777 |
Ambion 14K miRChip V1 [expanded format] |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA149241 |
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