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Status |
Public on Sep 01, 2012 |
Title |
ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTCF |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by array
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Summary |
Histone modifcations and CTCF binding at the c-myb locus were compared in cell lines with c-myb expressing, which are myeloblatic M1 cells and leukemia cells with virus integration, VS. M1 cells without c-myb expression induced by IL-6. Distribution of active histone marks at the c-myb gene and the upstream regions are associated with active c-myb transcription. The enrichment of all of these active histone marks decreased with differentiation-induced down-regulation of c-myb, but increased and spread in tumor cells.
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Overall design |
ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTCF
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Contributor(s) |
Zhang J, Wolff L |
Citation(s) |
22811527 |
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Submission date |
Dec 29, 2011 |
Last update date |
Nov 06, 2012 |
Contact name |
Junfang Zhang |
E-mail(s) |
zhangj3@mail.nih.gov
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Phone |
301-402-9232
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Fax |
301-594-3996
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Organization name |
NIH
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Department |
NCI-CCR
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Lab |
Laboratory of Cellular Oncology
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Street address |
37 Convent Dr.
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City |
Bethesda |
State/province |
MD |
ZIP/Postal code |
20892 |
Country |
USA |
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Platforms (4)
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GPL15050 |
Agilent-021202 MMLv3 [Probe Name version] |
GPL15072 |
Agilent-019497 MMLv2.0 [Probe Name version] |
GPL15073 |
Agilent-019859 MMLv2.1 [Probe Name version] |
GPL15074 |
Agilent-020349 MMLv2.2 [Probe Name version] |
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Samples (28)
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Relations |
BioProject |
PRJNA150353 |