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Series GSE3588 Query DataSets for GSE3588
Status Public on Nov 17, 2005
Title Insights into Dahl salt-sensitive hypertension revealed
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary The results of this study identified a number of pathways potentially important for the amelioration of hypertension and renal injury in SS-13BN/Mcw rats, and these results generated a series of testable hypotheses related to the role of the renal medulla in the complex mechanism of salt-sensitive hypertension.
Keywords: time course, microarray; 11ß-hydroxysteroid dehydrogenase; glucagon receptor; extracellular matrix; apoptosis
 
Overall design Rats were paired for microarray hybridization, and the results were analyzed. Each of the four between-group comparisons comprised three pairs of rats examined by six microarrays with dye switching for each pair. Dye switching was not necessary for within-group comparisons, because the two rats of each pair were equivalent in terms of their treatment status. The expression data from the present study were combined with those from 24 microarrays hybridized in our previous study and used to identify genes exhibiting the most distinct temporal patterns of expression between SS and SS-13BN/Mcw over the time course studied.
 
Contributor(s) Liang M, Yuan B, Rute E, Greene AS, Olivier M, Cowley AW Jr
Citation(s) 12488510
Submission date Nov 09, 2005
Last update date Mar 16, 2012
Contact name Mingyu Liang
E-mail(s) mliang@mcw.edu
Phone 414-456-8539
Organization name Medical College of Wisconsin
Department Physiology
Street address 8701 Watertown Plank Rd.
City Milwaukee
State/province WI
ZIP/Postal code 53226
Country USA
 
Platforms (1)
GPL3061 MCW Rattus norvegicus 2K Array Time Course 2003
Samples (24)
GSM82501 13LS vs 13HS-3 days 9-21-01-30_13-8 Cy5_13-2 cy3
GSM82502 13LS vs 13HS-3 days 9-21-01-31_13-2 Cy5_13-8 cy3
GSM82503 13LS vs 13HS-3 days 9-21-01-34_13-9 Cy5_13-3 cy3
Relations
BioProject PRJNA93681

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