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Series GSE38145 Query DataSets for GSE38145
Status Public on Jun 01, 2012
Title Integrative Gene Expression Profiling Reveals G6PD-Mediated Resistance to RNA-Directed Nucleoside Analogues in B-Cell Neoplasms
Organism Homo sapiens
Experiment type Expression profiling by array
Summary 8-amino-adenosine (8-NH2-Ado) inhibits RNA synthesis and specifically inhibits synthesis of mRNAs with short half-lives. We hypothesize that the mRNAs affected code for proteins important in apoptosis and glucose metabolism. Gene Expression Arrays will help us understand which gene families may be affected by this drug and give us a better understanding of mechanism of action of this drug
 
Overall design 1. MM.1S cells treated with 8-amino-adenosine for 0, 5 hrs and 17 hrs.
(myeloma cells sensitive to the drug)
2. U266 cells treated with 8-amino-adenosine for 0, 5 hrs and 17 hrs.
(myeloma cells resistant to the drug).
3. Jeko cells treated with 8-amino-adenosine for 0, 5 hrs and 17 hrs.
(Mantle cell lymphoma cells sensitive to drug)
4. Granta cells treated with 8-amino-adenosine for 0, 5 hrs and 17 hrs.
(Mantle cell lymphoma cells resistant to drug).
 
Contributor(s) McBrayer SK, Yarrington M, Qian J, Feng G, Shanmugam M, Gandhi V, Krett NL, Rosen ST
Citation(s) 22848499
Submission date May 22, 2012
Last update date Aug 26, 2019
Contact name Samuel McBrayer
E-mail(s) SamuelMcBrayer2011@u.northwestern.edu
Organization name Northwestern University
Street address 303 E Superior
City Chicago
ZIP/Postal code 60611
Country USA
 
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (45)
GSM935812 Myeloma cells sensitive to the drug at start point sample 1
GSM935813 Myeloma cells sensitive to the drug at start point sample 2
GSM935814 Myeloma cells sensitive to the drug at start point sample 3
Relations
BioProject PRJNA167344

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE38145_RAW.tar 6.2 Mb (http)(custom) TAR
Processed data included within Sample table
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