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| Status |
Public on Mar 31, 2013 |
| Title |
Agilent microarray analysis between a Dullard-heterozygous and a Dullard-homozygous E7.5 embryo |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To explore the loss of Dullurd function in mouse embryo development, we have performed the Agilent microarray analysis between a Dullard-heterozygous and a Dullard-homozygous E7.5 embryo. Our findings show that Dullard does not act in concert with BMP4 and Smad1/5/8, whereas loss of Dullard is associated with a reduced level of WNT/β-catenin signaling activity, accompanied by elevated expression of Wnt3 and WNT antagonists including Dkk1, Sfrp1 and Sfrp5 in mouse germ cell formation.
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| Overall design |
E7.5 mouse embryos were collected. One Dullard-heterozygous embryo and one Dullard-homozygous embryo were used for the analysis.
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| Contributor(s) |
Tanaka SS |
| Citation(s) |
23469192 |
| Submission date |
Jul 10, 2012 |
| Last update date |
Jan 19, 2018 |
| Contact name |
Satomi S Tanaka |
| E-mail(s) |
stanaka@kumamoto-u.ac.jp
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| Organization name |
Kumamoto University
|
| Department |
Institute of Molecular Embryology and Genetics
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| Lab |
Department of Kidney Development
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| Street address |
2-2-1 Honjo
|
| City |
Kumamoto |
| State/province |
Kumamoto |
| ZIP/Postal code |
860-0811 |
| Country |
Japan |
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| Platforms (1) |
| GPL10333 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA170249 |
