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| Status |
Public on Nov 14, 2013 |
| Title |
Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. Graphical Gaussian modeling (GGM) was applied to elucidate the interactions of gene clusters among the HCC and non-tumor lesions. Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC.
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| Overall design |
We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. Graphical Gaussian modeling (GGM) was applied to elucidate the interactions of gene clusters among the HCC and non-tumor lesions.
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| Contributor(s) |
Ueda T, Honda M, Horimoto K, Aburatani S, Saito S, Yamashita T, Sakai Y, Nakamura M, Takatori H, Sunagozaka H, Kaneko S |
| Citation(s) |
23485556 |
| |
| Submission date |
Feb 05, 2013 |
| Last update date |
Nov 14, 2013 |
| Contact name |
Masao Honda |
| E-mail(s) |
mhondag@gmail.com
|
| Phone |
0762652243
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| Organization name |
Kanazawa University
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| Department |
Gastroenterology
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| Street address |
Takara-Machi 13-1
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| City |
Kanazawa |
| ZIP/Postal code |
920-8641 |
| Country |
Japan |
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| Platforms (1) |
| GPL13536 |
Kanazawa Univ. Human Liver chip 10k |
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| Samples (105)
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| Relations |
| BioProject |
PRJNA188509 |
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