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| Status |
Public on Jul 01, 2013 |
| Title |
Expression data from E13.5 Fetal Liver LSK Hes1-GFP positive and E13.5 Fetal Liver LSK Hes1-GFP negative |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the majority of studies in the hematopoietic system focused on Notch signaling in lymphocyte differentiation and knowledge of individual Notch receptor roles in early hematopoiesis has been limited due to a paucity of genetic tools available To fate-map Notch receptor expression and pathway activity in the hematopoietic system we used tamoxifen-inducible CreER knock-in mice for individual Notch receptors in combination to a novel Notch reporter strain (Hes1GFP) and a conditional gain of function allele of Notch2 receptor (Rosa-lsl-ICN2).
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| Overall design |
E13.5 Foetal Liver lineage negative, cKit+, Sca1+ cells were sorted from Hes-GFP mice for RNA extraction and hybridization on Affymetrix microarrays
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| Contributor(s) |
Lobry C, Oh P, Aifantis I |
| Citation(s) |
23791481 |
| |
| Submission date |
May 08, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Camille Lobry |
| E-mail(s) |
camille.lobry@inserm.fr
|
| Organization name |
Inserm
|
| Department |
IRSL Inserm U944 / CNRS UMR7212
|
| Lab |
Lobry lab
|
| Street address |
16 rue de la Grange aux Belles
|
| City |
Paris |
| ZIP/Postal code |
75010 |
| Country |
France |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (4)
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| GSM1136150 |
E13.5 FL LSK HES1-GFP negative replicate 1 |
| GSM1136151 |
E13.5 FL LSK HES1-GFP negative replicate 2 |
| GSM1136152 |
E13.5 FL LSK HES1-GFP negative replicate 3 |
| GSM1136153 |
E13.5 FL LSK HES1-GFP positive replicate 1 |
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| This SubSeries is part of SuperSeries: |
| GSE46726 |
In Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis |
|
| Relations |
| BioProject |
PRJNA202201 |
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