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| Status |
Public on Dec 11, 2007 |
| Title |
Hypoxia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Systemic arterial smooth muscle cells are exposed to a broad range of oxygen concentrations under physiological conditions. Hypoxia can modulate the proliferative response of smooth muscle cells leading to speculation about its role in vasculogenesis, vascular remodelling and the pathogenesis of arterial disease. The effect of hypoxia has been inconsistent, however, with both enhanced proliferation and growth arrest reported. Nevertheless, these reports support an important effect of hypoxia on smooth muscle cell proliferation and, given its physiological and clinical relevance, this requires clarification. We posited that variation in O2 concentration, within the range that exists in vivo, may have different effects on the proliferation and survival of vascular smooth muscle cells.
Keywords: expression profiles of hypoxia (1% and 3%) in HASMC
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| Overall design |
Human aortic smooth muscle cells (HASMC) were propagated to passage 6 in SMGM-2 medium reached 80% confluence, the media was changed and the cells were incubated for a further 16 hrs or 48 hrs under either normoxic or hypoxic conditions (1% and 3%O2 ).
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| Contributor(s) |
Arab S, Basuray J, Ward M, Liu P |
| Citation(s) |
18055518 |
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| Submission date |
Apr 26, 2006 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Sara Arab |
| Organization name |
Toronto General Hospital
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| Department |
Cardiology
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| Lab |
M. Husain
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| Street address |
610 University Avenue
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| City |
Toronto |
| State/province |
ONT |
| ZIP/Postal code |
M5G 2M9 |
| Country |
Canada |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA95583 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE4725_RAW.tar |
20.4 Mb |
(http)(custom) |
TAR (of CEL, EXP) |
| Processed data included within Sample table |
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