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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 25, 2013 |
| Title |
Differential gene expression in the Lacrimal gland during development and onset of xerostomia in Sjögren’s syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from the NOD mouse capable of conferring Sjögren’s syndrome (SjS)-like disease in SjS-non-susceptible C57BL/6 mice.
In an attempt to define the molecular bases underlying onset of stomatitis sicca (xerostomia) in this C57BL/6.NOD-Aec1Aec2 mouse model, we have carried out a study utilizing genomic microarray technology.
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| Overall design |
The present study was designed to define the changing gene expression profiles within the Lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice at five time points representing a pre-disease stage (4 weeks), the early pre-clinical stage (8 weeks), the initial influx of leukocytes into the Lacrimal glands (12 weeks), the early clinical phase of autoimmunity (16 weeks), and the early onset of clinical SjSlike disease characterized by secretory dysfunction (20 weeks). The C57BL/6.NOD-Aec1Aec2 mouse is a model of primary SjS in which the Idd3 region of chromosome 3 and the Idd5 region of chromosome 1 derived from the NOD mouse were bred into the non-autoimmune C57BL/6 mouse, resulting in a SjS-like disease susceptibility that mimics both the pathophysiological characteristics and reduced secretory responses observed with NOD mice during development and onset of disease. This SjS-susceptible strain was designated C57BL/6.NOD-Aec1Aec2, where Aec1 corresponds to Idd3 (of chromosome 3) and Aec2 corresponds to Idd5 (of chromosome 1).
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| Contributor(s) |
Nguyen CQ, Sharma A, Lee BH, She J, McIndoe RA, Peck AB |
| Citation(s) |
19103199 |
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| Submission date |
Jun 20, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Ammon B Peck |
| E-mail(s) |
Peck@pathology.ufl.edu
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| Phone |
352-294-4211
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| Organization name |
University of Florida
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| Department |
Department of Infectious Diseases & Pathology
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| Street address |
1945 SW 16th Avenue
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| City |
Gainesville |
| State/province |
FL |
| ZIP/Postal code |
32610 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (26)
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| GSM1169517 |
Lacrimal glands at 4 weeks, biological rep1 |
| GSM1169518 |
Lacrimal glands at 4 weeks, biological rep2 |
| GSM1169519 |
Lacrimal glands at 4 weeks, biological rep3 |
| GSM1169520 |
Lacrimal glands at 4 weeks, biological rep4 |
| GSM1169521 |
Lacrimal glands at 8 weeks, biological rep1 |
| GSM1169522 |
Lacrimal glands at 8 weeks, biological rep2 |
| GSM1169523 |
Lacrimal glands at 8 weeks, biological rep3 |
| GSM1169524 |
Lacrimal glands at 8 weeks, biological rep4 |
| GSM1169525 |
Lacrimal glands at 8 weeks, biological rep5 |
| GSM1169526 |
Lacrimal glands at 8 weeks, biological rep6 |
| GSM1169527 |
Lacrimal glands at 12 weeks, biological rep1 |
| GSM1169528 |
Lacrimal glands at 12 weeks, biological rep2 |
| GSM1169529 |
Lacrimal glands at 12 weeks, biological rep3 |
| GSM1169530 |
Lacrimal glands at 12 weeks, biological rep4 |
| GSM1169531 |
Lacrimal glands at 12 weeks, biological rep5 |
| GSM1169532 |
Lacrimal glands at 12 weeks, biological rep6 |
| GSM1169533 |
Lacrimal glands at 16 weeks, biological rep1 |
| GSM1169534 |
Lacrimal glands at 16 weeks, biological rep2 |
| GSM1169535 |
Lacrimal glands at 16 weeks, biological rep3 |
| GSM1169536 |
Lacrimal glands at 16 weeks, biological rep4 |
| GSM1169537 |
Lacrimal glands at 16 weeks, biological rep5 |
| GSM1169538 |
Lacrimal glands at 20 weeks, biological rep1 |
| GSM1169539 |
Lacrimal glands at 20 weeks, biological rep2 |
| GSM1169540 |
Lacrimal glands at 20 weeks, biological rep3 |
| GSM1169541 |
Lacrimal glands at 20 weeks, biological rep4 |
| GSM1169542 |
Lacrimal glands at 20 weeks, biological rep5 |
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| Relations |
| BioProject |
PRJNA209303 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE48139_RAW.tar |
92.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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