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| Status |
Public on Jun 03, 2006 |
| Title |
Expression data from adult Rattus liver |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates.
We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment.
Keywords: a single ip injection of PCN (100 mg/kg), 8 h treatment
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| Overall design |
We chose to profile the gene expression pattern in the livers of adult rats to test the idea that PCN counteracts a wide variety of stresses by activating genes apart from drug metabolism.
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| Contributor(s) |
Guzelian J, Barwick JL, Hunter L, Phang TL, Quattrochi LC, Guzelian PS |
| Citation(s) |
16997903 |
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| Submission date |
May 31, 2006 |
| Last update date |
Mar 03, 2017 |
| Contact name |
Linda C Quattrochi |
| E-mail(s) |
linda.quattrochi@uchsc.edu
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| Phone |
303-315-3522
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| Organization name |
University of Colorado at Denver and Health Sciences
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| Department |
Medicine
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| Lab |
Quattrochi
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| Street address |
4200 E. 9th Ave, B146
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| City |
Denver |
| State/province |
CO |
| ZIP/Postal code |
80262 |
| Country |
USA |
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| Platforms (2) |
| GPL341 |
[RAE230A] Affymetrix Rat Expression 230A Array |
| GPL342 |
[RAE230B] Affymetrix Rat Expression 230B Array |
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| Samples (19)
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| GSM111891 |
corn oil control, biological rep3a |
| GSM111892 |
corn oil control, biological rep3b |
| GSM111893 |
corn oil control, biological rep4a |
| GSM111894 |
corn oil control, biological rep4b |
| GSM111895 |
corn oil control, biological rep5a |
| GSM111896 |
corn oil control, biological rep5b |
| GSM111897 |
PCN, biological rep1a |
| GSM111898 |
PCN, biological rep1b |
| GSM111899 |
PCN, biological rep2a |
| GSM111900 |
PCN, biological rep2b |
| GSM111901 |
PCN, biological rep3a |
| GSM111902 |
PCN, biological rep3b |
| GSM111903 |
PCN, biological rep4a |
| GSM111904 |
PCN, biological rep4b |
| GSM111905 |
PCN, biological rep5a |
| GSM111906 |
PCN, biological rep5B |
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| Relations |
| BioProject |
PRJNA96711 |
| Supplementary data files not provided |
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