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| Status |
Public on Feb 10, 2014 |
| Title |
Transcriptional consequences of manipulating the candidate schizophrenia susceptibility gene miR-137 in human neural progenitor cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In the largest published genome-wide association study (GWAS) of schizophrenia to date (PGC1), the most significant association (P = 1.6 X 10-11) was observed at an intronic variant (rs1625579) within the MIR137 host gene (MIR137HG). In this study we have performed genome-wide RNA profiling of a human foetal neural progenitor cell line following miR-137 manipulation, in order to identify gene expression changes through which genetic variation at the MIR137HG locus could confer susceptibility to schizophrenia.
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| Overall design |
Total RNA extracted from human neural progenitor cells manipulated with either mir137 inhibitor or mimic. 4 replicates per group. Genome wide transcript levels were then measured using gene expression microarrays.
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| Contributor(s) |
Hill MJ, Donocik JG, Killick R, Nuamah RA, Mein CA, Sainz-Fuertes R, Bray NJ |
| Citation(s) |
24556472 |
| |
| Submission date |
Aug 12, 2013 |
| Last update date |
Sep 05, 2019 |
| Contact name |
Matthew James Hill |
| Organization name |
Cardiff University
|
| Street address |
Maindy Road
|
| City |
Cardiff |
| ZIP/Postal code |
CF24 4HQ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (12)
|
| GSM1207149 |
human neural progenitor cell line_Control_replicate1 |
| GSM1207150 |
human neural progenitor cell line_Control_replicate2 |
| GSM1207151 |
human neural progenitor cell line_Control_replicate3 |
| GSM1207152 |
human neural progenitor cell line_Control_replicate4 |
| GSM1207153 |
human neural progenitor cell line_mir137_inhibitor_replicate1 |
| GSM1207154 |
human neural progenitor cell line_mir137_inhibitor_replicate2 |
| GSM1207155 |
human neural progenitor cell line_mir137_inhibitor_replicate3 |
| GSM1207156 |
human neural progenitor cell line_mir137_inhibitor_replicate4 |
| GSM1207157 |
human neural progenitor cell line_mir137_mimic_replicate1 |
| GSM1207158 |
human neural progenitor cell line_mir137_mimic_replicate2 |
| GSM1207159 |
human neural progenitor cell line_mir137_mimic_replicate3 |
| GSM1207160 |
human neural progenitor cell line_mir137_mimic_replicate4 |
|
| Relations |
| BioProject |
PRJNA214942 |
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