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Series GSE49793 Query DataSets for GSE49793
Status Public on Feb 10, 2014
Title Transcriptional consequences of manipulating the candidate schizophrenia susceptibility gene miR-137 in human neural progenitor cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary In the largest published genome-wide association study (GWAS) of schizophrenia to date (PGC1), the most significant association (P = 1.6 X 10-11) was observed at an intronic variant (rs1625579) within the MIR137 host gene (MIR137HG). In this study we have performed genome-wide RNA profiling of a human foetal neural progenitor cell line following miR-137 manipulation, in order to identify gene expression changes through which genetic variation at the MIR137HG locus could confer susceptibility to schizophrenia.
 
Overall design Total RNA extracted from human neural progenitor cells manipulated with either mir137 inhibitor or mimic. 4 replicates per group. Genome wide transcript levels were then measured using gene expression microarrays.
 
Contributor(s) Hill MJ, Donocik JG, Killick R, Nuamah RA, Mein CA, Sainz-Fuertes R, Bray NJ
Citation(s) 24556472
Submission date Aug 12, 2013
Last update date Sep 05, 2019
Contact name Matthew James Hill
Organization name Cardiff University
Street address Maindy Road
City Cardiff
ZIP/Postal code CF24 4HQ
Country United Kingdom
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (12)
GSM1207149 human neural progenitor cell line_Control_replicate1
GSM1207150 human neural progenitor cell line_Control_replicate2
GSM1207151 human neural progenitor cell line_Control_replicate3
Relations
BioProject PRJNA214942

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49793_RAW.tar 26.2 Mb (http)(custom) TAR
GSE49793_non-normalized.txt.gz 3.5 Mb (ftp)(http) TXT
Processed data included within Sample table

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