|
| Status |
Public on Apr 01, 2014 |
| Title |
A signature predicting poor prognosis in gastric and ovarian cancer represents a coordinated macrophage and stromal-response. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Genome wide mRNA expression profiling of 94 gastric tumours derived from Australian based cohort was performed. . From this data we identified a cluster of co-expressed genes termed the stromal response cluster which almost perfectly differentiates tumor from its non-malignant gastric tissue and hence can be regarded as a highly tumor-specific gene expression signature. We show that these genes are consistently co-expressed across a range of independent gastric datasets as well as other cancer types suggesting a conserved functional role in cancer.
|
| |
|
| Overall design |
Profiling of 94 primary gastric tumors on Affymetrix GeneChip Human Genome U133 Plus 2.0 Arrays. All tumors were collected with approvals from Peter MacCallum Cancer Center, Australia; the Research Ethics Review Committee; and signed informed patient consent.
|
| |
|
| Contributor(s) |
Boussioutas A, Busuttil RA |
| Citation(s) |
24658156, 29670108 |
| |
| Submission date |
Sep 23, 2013 |
| Last update date |
May 22, 2019 |
| Contact name |
Rita Ann Busuttil |
| E-mail(s) |
rita.busuttil@petermac.org
|
| Organization name |
Peter MacCallum Cancer Centre
|
| Department |
Research
|
| Lab |
Cancer Genetics and Genomics
|
| Street address |
St Andrews Pl
|
| City |
East Melbourne |
| State/province |
VIC |
| ZIP/Postal code |
3000 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (94)
|
|
| Relations |
| BioProject |
PRJNA221194 |
Less...
More...