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| Status |
Public on Oct 16, 2006 |
| Title |
Expression data from yeast treated with enediynes compared to gamma radiation |
| Organism |
Saccharomyces cerevisiae |
| Experiment type |
Expression profiling by array
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| Summary |
We are investigating the transcriptional response of yeast to treatment with enediynes or gamma radiation, which generate different extents of double or single strand breaks in DNA.
We used microarrays to detail the global programme of gene expression underlying the DNA damage response in yeast
Keywords: dose
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| Overall design |
Yeast were grown to mid log phase and treated with enediynes or gamma radiation (in biological triplicate) resulting in similar extents of cell killing. The responses were compared to each other and we have deciphered a gene expression profile that is specific for double and single strand breaks in DNA.
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| Contributor(s) |
Rebecca FC, Michael D, Joseph CP, Thomas BJ, Leona SD, Peter DC |
| Citation(s) |
17163986 |
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| Submission date |
Jul 13, 2006 |
| Last update date |
Jul 01, 2016 |
| Contact name |
Rebecca Catherine Fry |
| E-mail(s) |
rfry@unc.edu
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| Organization name |
UNC-Chapel Hill
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| Department |
Environmental Sciences and Engineering
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| Street address |
1213 MHRC
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| City |
Chapel Hill |
| ZIP/Postal code |
27599 |
| Country |
USA |
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| Platforms (1) |
| GPL90 |
[YG_S98] Affymetrix Yeast Genome S98 Array |
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| Samples (18)
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| GSM120131 |
Esperamicin, biological rep1 |
| GSM120132 |
Esperamicin, biological rep2 |
| GSM120133 |
Esperamicin, biological rep3 |
| GSM120134 |
neocarzinostatin, biological rep1 |
| GSM120135 |
neocarzinostatin, biological rep2 |
| GSM120136 |
neocarzinostatin, biological rep3 |
| GSM120137 |
yeast treated with methanol, biological rep1 |
| GSM120138 |
methanol, biological rep2 |
| GSM120139 |
methanol, biological rep3 |
| GSM120140 |
yeast treated with mock gamma, biological rep1 |
| GSM120141 |
yeast treated with mock gamma, biological rep2 |
| GSM120142 |
yeast treated with mock gamma, biological rep3 |
| GSM120143 |
gamma radiation, biological rep1 |
| GSM120144 |
gamma radiation, biological rep2 |
| GSM120145 |
gamma radiation, biological rep3 |
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| Relations |
| BioProject |
PRJNA96303 |
| Supplementary data files not provided |
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