|
| Status |
Public on Dec 13, 2013 |
| Title |
The DNA Double-Strand Break Response Is Abnormal in Myeloblasts From Patients With Therapy-Related Acute Myeloid Leukemia [NimbleGen] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
In order to examine if acquired copy number alterations in DNA repair genes is commonly observed in therapy-related AML, we used this custom built NimbleGen array with dense tiling of probes in 170 DNA repair genes to interrogate paired normal (skin) and tumor (bone marrow) samples.
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| |
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| Overall design |
DNA was extracted from bone marrow cells or skin biopsy samples taken directly from patients after written informed consent. DNA was labeled and hybridized to custom built NimbleGen array CGH chips containing dense tiling in 170 DNA repair genes to detect copy number amplification.
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| |
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| Contributor(s) |
Jacoby MA, de Jesus Pizarro R, Shao J, Koboldt D, Fulton RS, Zhao G, Wilson RK, Walter MJ |
| Citation(s) |
24304937 |
| |
| Submission date |
Dec 12, 2013 |
| Last update date |
Mar 17, 2014 |
| Contact name |
Matt Walter |
| E-mail(s) |
mjwalter@dom.wustl.edu
|
| Organization name |
washington university in st.louis school of medicine
|
| Department |
oncology
|
| Street address |
4940 parkview
|
| City |
st.louis |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18053 |
NimbleGen Human CGH array [091130_HG18_DL_CGH; condensed PROBE_ID version] |
|
| Samples (30)
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| This SubSeries is part of SuperSeries: |
| GSE53251 |
The DNA Double-Strand Break Response Is Abnormal in Myeloblasts From Patients With Therapy-Related Acute Myeloid Leukemia |
|
| Relations |
| BioProject |
PRJNA231541 |
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