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| Status |
Public on Mar 31, 2014 |
| Title |
Gene expression profiling in psoriatic lesional and non-lesional skin [brodalumab treatment] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. Furthermore, we explored the effects of various doses of brodalumab on lesional skin over time.
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| Overall design |
From each of the 25 psoriasis patients, we obtained two pre-dose biopsies, one from a lesion and the other from non-lesional skin in the same general body geography, and two post-dose biopsies. Total RNA was extracted from 6mm punch biopsies that were split in half. A total of 99 samples were run on Affymetrix HU133 Plus 2.0 microarrays. There was no paired non-lesional sample for 'T_lesional_pre-dose' (skn55789).
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| |
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| Contributor(s) |
Bigler J, Timour M, Kerkof K, Russell CB |
| Citation(s) |
24646743 |
| Submission date |
Dec 20, 2013 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Jeannette Bigler |
| E-mail(s) |
jeannette.bigler@bjgroupllc.com
|
| Organization name |
BJ Group, LLC
|
| Street address |
3200 NE 92nd Street
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98115 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (99)
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| Relations |
| BioProject |
PRJNA232372 |
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