|
| Status |
Public on Jan 07, 2015 |
| Title |
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hyper-trimethylation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression changes were analyzed in 2 acute lymphoblastic leukemia cell lines treated with the GSK126 EZH2 inhibitor using Affymetrix Human Genome U133 Plus 2.0 arrays.
|
| |
|
| Overall design |
Two ALL cell lines (SUP-B8, NALM-6) were treated with DMSO (control) or GSK126 at 0.5 uM for 72 hours. Two biological replicates are included for each treatment group.
|
| |
|
| Contributor(s) |
Ott H, Bai Y, Creasy C, McCabe M |
| Citation(s) |
25253781 |
| |
| Submission date |
Apr 21, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Matteo Righi |
| E-mail(s) |
m.righi@autolus.com
|
| Organization name |
Autolus Therapeutics
|
| Street address |
The MediaWorks, 191 Wood Ln
|
| City |
London |
| State/province |
London |
| ZIP/Postal code |
W12 7FP |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (8)
|
| GSM1372113 |
SUP-B8 DMSO vehicle at 72 hrs, Biological rep1 |
| GSM1372114 |
SUP-B8 DMSO vehicle at 72 hrs, Biological rep2 |
| GSM1372115 |
SUP-B8 GSK126 0.5 uM at 72 hrs, Biological rep1 |
| GSM1372116 |
SUP-B8 GSK126 0.5 uM at 72 hrs, Biological rep2 |
| GSM1372117 |
NALM-6 DMSO vehicle at 72 hrs, Biological rep1 |
| GSM1372118 |
NALM-6 DMSO vehicle at 72 hrs, Biological rep2 |
| GSM1372119 |
NALM-6 GSK126 0.5 uM at 72 hrs, Biological rep1 |
| GSM1372120 |
NALM-6 GSK126 0.5 uM at 72 hrs, Biological rep2 |
|
| Relations |
| BioProject |
PRJNA245049 |
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