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Series GSE59762 Query DataSets for GSE59762
Status Public on Mar 01, 2015
Title Expression data from CpG treated Common Lymphoid Progenitors
Organism Mus musculus
Experiment type Expression profiling by array
Summary Common Lymphoid Progenitors (CLPs) have two subsets, Ly-6d- which are mutli-potent, and Ly-6d, which derive from Ly-6d- and are committeed to the B-cell fate. Treatment of a mouse with CpG DNA causes an inflammatory response that alters both subsets. We used expression data to understand the changes in transcription in the transition of Ly-6d- CLPs to Ly-6d+ CLPs ion the presence and absence of CpG induced inflammation.
 
Overall design C57BL/6 mice were treated over 10 days with either PBS or 50 ug of CpG1826. On day 10, bone marrow was harvested and CLPs populations were sorted by flow cytometry directly into RNAeasy buffer (Qiagen).
 
Contributor(s) Baratono S, Behrens EM
Citation(s) 25639361
Submission date Jul 25, 2014
Last update date Feb 21, 2018
Contact name Edward M Behrens
E-mail(s) behrens@email.chop.edu
Organization name The Children's Hospital of Philadelphia
Street address ARC 1102
City Philadelphia
State/province Pennsylvania
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL16570 [MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]
Samples (11)
GSM1446177 Ly-6D+CLPs_CpG_ rep1
GSM1446178 Ly-6D+CLPs_CpG_ rep2
GSM1446179 Ly-6D+CLPs_CpG_ rep3
Relations
BioProject PRJNA256162

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59762_RAW.tar 92.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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