|
| Status |
Public on Mar 01, 2015 |
| Title |
Expression data from CpG treated Common Lymphoid Progenitors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Common Lymphoid Progenitors (CLPs) have two subsets, Ly-6d- which are mutli-potent, and Ly-6d, which derive from Ly-6d- and are committeed to the B-cell fate. Treatment of a mouse with CpG DNA causes an inflammatory response that alters both subsets. We used expression data to understand the changes in transcription in the transition of Ly-6d- CLPs to Ly-6d+ CLPs ion the presence and absence of CpG induced inflammation.
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| Overall design |
C57BL/6 mice were treated over 10 days with either PBS or 50 ug of CpG1826. On day 10, bone marrow was harvested and CLPs populations were sorted by flow cytometry directly into RNAeasy buffer (Qiagen).
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| Contributor(s) |
Baratono S, Behrens EM |
| Citation(s) |
25639361 |
| |
| Submission date |
Jul 25, 2014 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Edward M Behrens |
| E-mail(s) |
behrens@email.chop.edu
|
| Organization name |
The Children's Hospital of Philadelphia
|
| Street address |
ARC 1102
|
| City |
Philadelphia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA256162 |
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