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| Status |
Public on Jul 30, 2014 |
| Title |
Epigenetic activation of neuronal gene expression by JMJD3 is required for postnatal and adult brain neurogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The epigenetic mechanisms that enable lifelong neurogenesis from neural stem cells (NSCs) in the adult mammalian brain are poorly understood. Here we show that JMJD3, a histone H3-lysine 27 (H3K27) demethylase, acts as a critical activator of neurogenesis.
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| Overall design |
3 biological replicates of JMJD3 null (P9 UBC-Cre/ERT2;Jmjd3F/F) and 3 biological replicates of littermate controls were used to analyze the effect of JMJD3 deletion on gene expression.
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| Contributor(s) |
Park DH, Lim DA, Liu SJ |
| Citation(s) |
25176653 |
| Submission date |
Jul 29, 2014 |
| Last update date |
Jun 14, 2018 |
| Contact name |
John Liu |
| E-mail(s) |
john.liu@ucsf.edu
|
| Organization name |
UCSF
|
| Street address |
35 Medical Center Way
|
| City |
SAN FRANCISCO |
| State/province |
California |
| ZIP/Postal code |
94143 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA256992 |
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