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| Status |
Public on Aug 15, 2016 |
| Title |
Gene expression based profiling of Mycobacterium tuberculosis infected primary murine osteoclasts. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Mycobacterium tuberculosis(Mtb) is known to reside in cells of innate immune system- macrophages and dendritic cells. A variety of non -conventional cell typeslike adipocytes, mesenchyal stem cells and osteoclasts can also be infected with Mtb. However, cellular transcriptional adapations enabling survival of Mtb in these cells remain known.
We used microarrays to understand global changes in transcriptional profiling during macrophage to osteoclast transition in presence of Mycobacterium tuberculosis.
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| Overall design |
Time-series changes in expression were seen in presence of Mycobacterium tuberculosis on 0, 2, 3 and 4 days post infection during macrophage to osteoclast transition.
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| Contributor(s) |
Singh Attri K, Gokhale RS |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 18, 2014 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Kuldeep Singh Attri |
| E-mail(s) |
kuldeep.attri@igib.in
|
| Phone |
+91-9953322057
|
| Organization name |
CSIR-IGIB
|
| Department |
Systems Biology
|
| Lab |
Rajesh Gokhale Lab
|
| Street address |
Sukhdev Vihar
|
| City |
New Delhi |
| State/province |
Delhi |
| ZIP/Postal code |
110020 |
| Country |
India |
| |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA261398 |
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