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| Status |
Public on Jan 01, 2016 |
| Title |
Effects of Morus alba L. (Mulberry) Leaf Extract in Hypercholesterolemic Mice on Suppression of Cholesterol Synthesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate effects of intake of mulberry leaf extracts on hypercholesterolemia, we performed gene expression profiling on rat liver by microarray analysis.
Microarray analysis revealed that mulberry leaf extracts up-regulated the gene expression involved in suppression of cholesterol synthesis and stimulation of innate-adaptive Immunity.
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| Overall design |
Mice were fed a high-cholesterol diet without/with orally administration of mulberry leaf extracts for 4 weeks. Livers were taken for RNA extraction and hybridization on Agilent microarrays.
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| Contributor(s) |
Kobayashi Y, Miyazawa M, Araki M, Kamei A, Abe K, Hiroi T, Hirokawa T, Aoki N, Ohsawa T, Kojima T |
| Citation |
Kobayashi Y, Miyazawa M, Araki M, Kamei A, Abe K, et al. (2015) Effects of Morus alba L (Mulberry) Leaf Extract in Hypercholesterolemic Mice on Suppression of Cholesterol Synthesis. J Pharmacogn Nat Prod 1:113. http://dx.doi.org/10.4172/jpnp.1000113
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| Submission date |
Feb 11, 2015 |
| Last update date |
Apr 04, 2016 |
| Contact name |
Yukihiro Kobayashi |
| E-mail(s) |
yukihiro@kaiyodai.ac.jp
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| Organization name |
Tokyo University of Marine Science and Technology
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| Department |
Department of Marine Biosciences
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| Lab |
Laboratory of Aquatic Resource Utilization
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| Street address |
4-5-7, Konan
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| City |
Minato-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
108-8477 |
| Country |
Japan |
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| Platforms (1) |
| GPL19771 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Gene-level version) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA275187 |
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