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| Status |
Public on Aug 03, 2015 |
| Title |
Expression data from cortical thymic epithelial cells ectopically expressing Aire |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Aire in medullary thymic epithelial cells plays an essential role in the negative selection through expression of broad arrays of tissue-restricted antigens.
We asked whether Aire could also activate the expression of tissue-restricted antigens in cortical thymic epithelial cells.
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| Overall design |
We established a semi-knockin strain of NOD-background mice expressing Aire under control of the promoter of β5t, a thymoproteasome expressed exclusively in the cortex. We extracted RNA from cortical thymic epithelial cells ectopically expressing Aire and hybridization was performed on Affymetrix. microarrays.
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| Contributor(s) |
Matsumoto M, Nishijima H |
| Citation(s) |
26453754 |
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| Submission date |
Jun 26, 2015 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Mitsuru Matsumoto |
| E-mail(s) |
mitsuru@tokushima-u.ac.jp
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| Organization name |
Institute for Enzyme Research, Tokushima University
|
| Department |
Division of Molecular Immunology
|
| Street address |
3-18-15 Kuramoto
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| City |
Tokushima |
| ZIP/Postal code |
770-8503 |
| Country |
Japan |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA288319 |
