|
| Status |
Public on Oct 01, 2015 |
| Title |
LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer [array] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
HOTAIR is up-regulated in tamoxifen-resistant breast cancer tissues compared to their primary counterparts. Mechanistically, HOTAIR is a direct target of ER-mediated transcriptional repression and is thus restored upon the blockade of ER signaling, either by hormone deprivation or tamoxifen treatment.
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| |
|
| Overall design |
Lentiviral infected Ctrl or HOTAIR stable MCF7 cells were deprived for 3 days and then treated with ethanol or 1 nM E2 for 6h, cells were collected for RNA extraction.
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| |
|
| Contributor(s) |
Yu J, Xue X |
| Citation(s) |
26364613 |
| |
| Submission date |
Jul 24, 2015 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Jindan Yu |
| E-mail(s) |
jindan.yu@emory.edu
|
| Organization name |
Emory University
|
| Department |
Urology
|
| Lab |
Jindan Yu's lab
|
| Street address |
E330, 1760 Haygood Dr NE
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30322 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE71298 |
LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer |
|
| Relations |
| BioProject |
PRJNA290857 |
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