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| Status |
Public on Sep 23, 2016 |
| Title |
RUNX1-ETO (RE) murine hematopoietic stem/progenitor cells (HSPCs) treated with GM-CSF |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
GM-CSF signaling was previously reported to have a negative effect on a murine model of (8;21)-induced leukemia. Gene expression profiling of MigR1 (Mig) control and RUNX1-ETO (RE), the oncofusion protein generated from t(8;21), murine Lin-/c-Kit+ hematopoietic stem/progenitor cells (HSPCs) was conducted to further elucidate the mechanisms mediating the negative effect induced by GM-CSF signaling in t(8;21) cells,
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| Overall design |
Gene expression profiling of control MigR1 (Mig) and MigR1-RUNX1-ETO (RE) Lin-/c-Kit+murine hematopoietic stem/progenitor cells (HSPCs) with and without 10ng/mL GM-CSF treatment
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| Contributor(s) |
Weng S, Matsuura S, Mowery CT, Stoner SA, Lam K, Ran D, Davis AG, Lo MC, Zhang DE |
| Citation(s) |
27389055 |
| |
| Submission date |
Sep 01, 2015 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Dong-Er Zhang |
| E-mail(s) |
d7zhang@ucsd.edu
|
| Phone |
8588225372
|
| Organization name |
UCSD Moores Cancer Center
|
| Street address |
3855 Health Sciences Drive
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (12)
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| Relations |
| BioProject |
PRJNA294367 |
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