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Series GSE72968 Query DataSets for GSE72968
Status Public on Aug 17, 2017
Title Molecular subtypes of metastatic colorectal cancer are predictive of patient response to chemo and targeted therapies (part 1)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We report that previously described molecular subtypes of colorectal cancer are associated with the response to therapy in patients with metastatic disease. We also identified a patient population with high FOLFIRI sensitivity, as indicated by their 2.7-fold longer overall survival when treated with FOLFIRI, as first-line regimen, instead of FOLFOX. Our results demonstrate the interest of molecular classifications to develop tailored therapies for patients with metastatic colorectal cancer.
 
Overall design The COSIVAL cohort was a retrospective multicenter study involving 6 French hospitals (CHU Trousseau - Tours, Hôpital Purpan - Toulouse, Hôpital Central - Nancy, Hôpital Dupuytren - Limoges, Hôpital Ambroise Paré – Boulogne Billancourt, Hopital de Lille ) and 2 comprehensive Cancer Centers (ICM, Montpellier; Institut Bergonié, Bordeaux) and contained 68 patients
 
Contributor(s) Del Rio M, Mollevi C, Martineau P
Citation(s) 28284171, 28659146, 30863148
Submission date Sep 12, 2015
Last update date Mar 25, 2019
Contact name Pierre Martineau
E-mail(s) pierre.martineau@inserm.fr
Phone +33 4 67 61 37 43
Organization name Inserm
Department IRCM
Street address 208 Rue des Apothicaires
City Montpellier Cedex 5
ZIP/Postal code 34298
Country France
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (68)
GSM1875897 Primary_Tumor 01_010
GSM1875898 Primary_Tumor 02_005
GSM1875899 Primary_Tumor 02_006
This SubSeries is part of SuperSeries:
GSE72970 Molecular subtypes of metastatic colorectal cancer are predictive of patient response to chemo and targeted therapies
Relations
BioProject PRJNA295463

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE72968_RAW.tar 313.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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