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| Status |
Public on Oct 31, 2016 |
| Title |
MiROvaR, a microRNA-based predictor of early relapse for ovarian cancer patients [validation set; OC133] |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Despite a pathological complete response, risk-of-relapse remains a challenge for most of epithelial ovarian cancer (EOC) patients and an ad-hoc predictor can be a valuable clinical tool. We developed a 35 miRNAs-based predictor of Risk of Ovarian Cancer Relapse (MiROvaR) using a training set of patients from MITO-2 (Multicentre Italian Trials in Ovarian Cancer-2; Pignata S et al. J Clin Oncol. 2011 Sep 20). MiROvaR performance was confirmed in two independent validation cohorts.
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| Overall design |
Fresh frozen samples were collected from a series of 133 consecutive ovarian cancer patients who underwent primary surgery at CRO, National Cancer Institute (Aviano, Italy) and were profiled on Illumina platform at INT-Milan. Ethical Statement: All of the patients whose biological samples were included in the study, gave their signed consent to donate the tissues remaining after the diagnostic procedures for research purposes. The study was approved by the Independent Ethics Committee of the Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (INT-MI) where the miRNA profile was performed. Clinical codes: Age (years) Histology: according to International Federation of Gynecological and Obstetrics guidelines ( 1: Serous; 2: Mucinous; 3: Endometrioid; 4: Undifferentiated; 5: Clear cell; 6: Mixed or other; NA: Missing information) Stage: according to International Federation of Gynecological and Obstetrics guidelines Grading: according to WHO (BL: border line; G1: well differentiated; G2: moderately differentiated; G3: poorly differentiated; undiff: undifferentiated; NA: missing information) Debulking: NED: not evident disease; mRD: minimal residual disease (<1cm) ; GRD: gross residual disease (>1cm); NO: not operated; NA: missing information Time to relapse (TTR, months) code: 0=no relapse; 1=relapse Overall survival (OS, months) code: 0=alive; 1=dead
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| Contributor(s) |
De Cecco L |
| Citation missing |
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| |
| Submission date |
Sep 29, 2015 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Loris De Cecco |
| E-mail(s) |
loris.dececco@istitutotumori.mi.it
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| Organization name |
IRCSS Istituto Nazionale Tumori
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| Street address |
via Venezian 1
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| City |
Milan |
| ZIP/Postal code |
20133 |
| Country |
Italy |
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| Platforms (1) |
| GPL8179 |
Illumina Human v2 MicroRNA expression beadchip |
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| Samples (133)
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| This SubSeries is part of SuperSeries: |
| GSE73584 |
MiROvaR, a microRNA-based predictor of early relapse for ovarian cancer patients |
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| Relations |
| BioProject |
PRJNA297361 |
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