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Series GSE74659 Query DataSets for GSE74659
Status Public on Nov 05, 2015
Title SCL and LMO1 reprogram thymocytes into self-renewing cells.
Organism Mus musculus
Experiment type Expression profiling by array
Summary The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1.
 
Overall design Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes.
 
Contributor(s) Tremblay M, Veiga V, Lemieux S, Hoang T
Citation(s) 25522233
Submission date Nov 04, 2015
Last update date Aug 08, 2021
Contact name mathieu tremblay
E-mail(s) m.tremblay@umontreal.ca
Organization name Université de Montréal/IRIC
Street address 2950 Chemin de Polytechnique, pav marcelle-coutu 1432
City Montreal
State/province QC
ZIP/Postal code h3t 1j4
Country Canada
 
Platforms (1)
GPL339 [MOE430A] Affymetrix Mouse Expression 430A Array
Samples (6)
GSM1924962 SCLtg LMO1tg #1
GSM1924963 SCLtg LMO1tg #2
GSM1924964 SCLtg LMO1tg #3
Relations
BioProject PRJNA301090

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74659_RAW.tar 19.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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