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Status |
Public on Nov 05, 2015 |
Title |
SCL and LMO1 reprogram thymocytes into self-renewing cells. |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1.
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Overall design |
Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes.
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Contributor(s) |
Tremblay M, Veiga V, Lemieux S, Hoang T |
Citation(s) |
25522233 |
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Submission date |
Nov 04, 2015 |
Last update date |
Aug 08, 2021 |
Contact name |
mathieu tremblay |
E-mail(s) |
m.tremblay@umontreal.ca
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Organization name |
Université de Montréal/IRIC
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Street address |
2950 Chemin de Polytechnique, pav marcelle-coutu 1432
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City |
Montreal |
State/province |
QC |
ZIP/Postal code |
h3t 1j4 |
Country |
Canada |
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Platforms (1) |
GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
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Samples (6)
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Relations |
BioProject |
PRJNA301090 |