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Status |
Public on Sep 07, 2016 |
Title |
Effect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TEM) |
Platform organism |
Homo sapiens |
Sample organism |
Macaca mulatta |
Experiment type |
Expression profiling by array
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Summary |
Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in changes to T and/or NK cell population dynamics that would reflect physiologic IL-15 function. The results provide important information on the specific role IL-15 plays in effector memory T cell and NK cell homeostasis, noting that effector memory T cells but not NK cells can be maintained in the absence of IL-15 signaling by the activity of other cytokines.
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Overall design |
Sort-purified CD8+ TEM from PBMC, before and after treatment with IgG1 Ab and anti-IL15 Ab
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Contributor(s) |
DeGottardi MQ, Okoye AA, Vaidya M, Talla A, Sekaly R, Picker LJ |
Citation(s) |
27430715 |
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Submission date |
Jan 12, 2016 |
Last update date |
Aug 13, 2018 |
Contact name |
AARTHI TALLA |
E-mail(s) |
axt427@case.edu
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Phone |
4047695226
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Organization name |
Case Western Reserve University School of Medicine
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Department |
Pathology
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Lab |
Dr.Rafick Sekaly
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Street address |
2103 Cornell Rd
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City |
Cleveland |
State/province |
OH |
ZIP/Postal code |
44106 |
Country |
USA |
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Platforms (1) |
GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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Samples (23)
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This SubSeries is part of SuperSeries: |
GSE76797 |
Effect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques |
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Relations |
BioProject |
PRJNA308600 |