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| Status |
Public on Feb 24, 2019 |
| Title |
Altered cell signaling in the absence of Dynamin function: a transcriptomic approach from yeast to humans (yeast) |
| Platform organisms |
Schizosaccharomyces pombe; Saccharomyces cerevisiae |
| Sample organism |
Saccharomyces cerevisiae |
| Experiment type |
Expression profiling by array
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| Summary |
Dynamins are large multidomain GTPases involved in membrane scission. We have investigated the transcriptional consequences of deleting Vps1, a DNM2 homologue, in the yeast Saccharomyces cerevisiae. Interestingly, the vps1∆ mutation causes strong transcriptional defects also in yeast.
Data suggest that DNM2 and Vps1 play an essential regulatory role connecting several membrane-related processes including endocytosis, lipid homeostasis and different signal transduction pathways.
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| Overall design |
Transcriptomic data from wild type and vps1Δ strains under normal growth conditions were compared. Three biological independient replicates were use for each strain.
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| Contributor(s) |
Morillo-Huesca M, Dominguez-Sanchez MS, Alfonso-Perez T, Perez-Alegre M, Andujar E, Bachetti V, Garcia-Dominguez M, Reyes JC |
| Citation missing |
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| Submission date |
Feb 24, 2016 |
| Last update date |
Feb 25, 2019 |
| Contact name |
Eloisa Andujar |
| E-mail(s) |
eloisa.andujar@cabimer.es
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| Phone |
954467828
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| Organization name |
CABIMER-CSIC
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| Department |
GENOMICS UNIT
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| Street address |
Avda Americo vespucio s/n
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| City |
Sevilla |
| State/province |
Sevilla |
| ZIP/Postal code |
41092 |
| Country |
Spain |
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| Platforms (1) |
| GPL2529 |
[Yeast_2] Affymetrix Yeast Genome 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA313065 |
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