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Series GSE78721 Query DataSets for GSE78721
Status Public on Dec 31, 2018
Title Genome–wide gene expression profile of adipocytes and infiltration macrophages obtained from abdominal (visceral and subcutaneous) and peripheral (thigh) adipose depots from Normal Glucose Tolerant and Type 2 Diabetics Asian Indians
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We have identified molecular-level alternations in different adipose depots (thigh, visceral and subcutaneous) of Asian Indians (both male and female) suffering from type-2 diabetes as compared to age and BMI matched normal glucose tolerant subjects by functional analysis of differentially expressed genes, and correlation of gene expression estimates with measured intermediate traits associated with T2D and its related co-morbidities (Hb1Ac, HOMA-B, HOMA-R, NEFA, Triglyceride, Total Cholesterol, HDL, LDL, VLDL, Leptin, Adiponectin, TNF-α, Serum- Creatinine, IL-6, High sensitivity - serum-creatinine (hs-CRP) and also size of adipocytes).

Funding:
Grant Id: 5/4/8/2012-RMC
Grant title: Clinical, Biochemical and Cellular Correlates of Transcriptome of Adipose Tissue Among Type-2 Diabetics
Name of the funding source: Indian Council for Medical Research
 
Overall design We have recruited 30 controls & 30 diabetic subjects undergoing femur bone surgery and 16 controls & 19 diabetic subjects undergoing abdominal surgery (two samples from each subject, one subcutaneous and one visceral fat biopsy were extracted). So total 130 samples were obtained and analyzed for genome –wide gene expression profile of Adipocytes and infiltration macrophages from three different depots of adipose tissue.
 
Contributor(s) Mathur SK, Saxena A, Tiwari P
Citation(s) 30671081, 30894049, 32847136
Submission date Feb 26, 2016
Last update date Nov 02, 2020
Contact name Dr. Sandeep Kumar Mathur
E-mail(s) drsandeepmathur@rediffmail.com
Phone +91-9414048666
Organization name SMS Medical College and Hospital
Department Department of Endocrinology
Lab Molecular Genetics Research Lab
Street address Tonk Road
City Jaipur
State/province Rajasthan
ZIP/Postal code 302015
Country India
 
Platforms (1)
GPL15207 [PrimeView] Affymetrix Human Gene Expression Array
Samples (130)
GSM2349019 20140522_155148_002: Normal
GSM2349020 20140523_121040_001: Normal
GSM2349021 20140703_142346_001: Normal
Relations
BioProject PRJNA313321

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE78721_RAW.tar 223.3 Mb (http)(custom) TAR (of CEL)
GSE78721_log2_normalized_with_ercc_control_probe_sets.txt.gz 33.7 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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