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| Status |
Public on Jul 28, 2016 |
| Title |
White adipose tissue browning in the R6/2 mouse model of Huntington's disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We investigated gene expression signatures in subcutaneous inguinal adipose tissue obtained from wild type and R6/2 mice with the aim to identify gene expression changes and signalling pathway alterations in adipose tissue relevant to HD.
Gene expression was assessed using Affymetrix GeneChip® Mouse Gene 2.0 ST Array. Target genes were technically validated using real-time quantitative PCR.
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| Overall design |
12 subcutaneous inguinal white adipose tissue samples were analyzed by affymetrix: 6 wild-type samples; 6 R6/2 mouse samples.
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| Contributor(s) |
McCourt AC, Jakobsson L, Larsson S, Holm C, Piel S, Elmér E, Björkqvist M |
| Citation(s) |
27486903 |
| |
| Submission date |
Mar 30, 2016 |
| Last update date |
Sep 25, 2019 |
| Contact name |
Maria Björkqvist |
| E-mail(s) |
maria.bjorkqvist@med.lu.se
|
| Organization name |
Lund University
|
| Department |
Experimental Medical Sciences
|
| Lab |
Brain Disease Biomarker Unit
|
| Street address |
Sölvegatan 17
|
| City |
Lund |
| State/province |
Skåne |
| ZIP/Postal code |
221 84 |
| Country |
Sweden |
| |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (12)
|
| GSM2101455 |
subcutaneous inguinal adipose tissue R6/2 - 1 |
| GSM2101456 |
subcutaneous inguinal adipose tissue R6/2 - 2 |
| GSM2101457 |
subcutaneous inguinal adipose tissue R6/2 - 3 |
| GSM2101458 |
subcutaneous inguinal adipose tissue wild type - 1 |
| GSM2101459 |
subcutaneous inguinal adipose tissue R6/2 - 4 |
| GSM2101460 |
subcutaneous inguinal adipose tissue R6/2 - 5 |
| GSM2101461 |
subcutaneous inguinal adipose tissue wild type - 2 |
| GSM2101462 |
subcutaneous inguinal adipose tissue wild type - 3 |
| GSM2101463 |
subcutaneous inguinal adipose tissue wild type - 4 |
| GSM2101464 |
subcutaneous inguinal adipose tissue wild type - 5 |
| GSM2101465 |
subcutaneous inguinal adipose tissue R6/2 - 6 |
| GSM2101466 |
subcutaneous inguinal adipose tissue wild type - 6 |
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| Relations |
| BioProject |
PRJNA316818 |
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