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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 24, 2016 |
| Title |
Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by array
Expression profiling by high throughput sequencing
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| Summary |
To investigate the role of NKX3.1 in prostate differentiation, we employed transcriptome analysis of mouse seminal vesicle (from 15-month-old Nkx3.1+/+ mice); mouse prostate (from 4-month-old Nkx3.1+/+ and Nkx3.1-/- mice); human prostate cells (RWPE1 cells engineered with empty vector (altered pTRIPZ), NKX3.1 wild type over-expression, and NKX3.1 (T164A) mutant over-expression); and tissue recombinants (generated from combining engineered mouse epithelial cells (seminal vesicle epithelial cells or prostate epithelial cells from 2-month-old mice) and rat UGS mesenchymal cells). Mouse tissue or human cells were snap frozen for subsequent molecular analysis.
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series
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| Citation(s) |
27339988 |
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| Submission date |
May 13, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Antonina Mitrofanova |
| E-mail(s) |
mitrofanova.antonina@hotmail.com
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| Organization name |
Rutgers University
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| Street address |
65 Bergen Street, Rm 923B
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| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07107 |
| Country |
USA |
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| Platforms (3) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (52)
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| GSM2131444 |
Nkx3.1 +/+ Seminal Vesicle, 5656sv |
| GSM2152244 |
Nkx3.1 +/+ Prostate, CAD37 |
| GSM2152245 |
Nkx3.1 +/+ Prostate, CAD38 |
| GSM2152246 |
Nkx3.1 +/+ Prostate, CAD39 |
| GSM2152247 |
Nkx3.1 +/+ Prostate, CAD40 |
| GSM2152248 |
Nkx3.1 +/+ Prostate, CAD41 |
| GSM2152249 |
Nkx3.1 +/+ Prostate, CAD42 |
| GSM2152250 |
Nkx3.1 -/- Prostate, CAD61 |
| GSM2152251 |
Nkx3.1 -/- Prostate, CAD62 |
| GSM2152252 |
Nkx3.1 -/- Prostate, CAD63 |
| GSM2152253 |
Nkx3.1 -/- Prostate, CAD64 |
| GSM2152254 |
Nkx3.1 -/- Prostate, CAD65 |
| GSM2152255 |
Nkx3.1 -/- Prostate, CAD66 |
| GSM2152391 |
SVE + UGM, CAD101 |
| GSM2152392 |
SVE + UGM, CAD102 |
| GSM2152393 |
SVE + UGM, CAD103 |
| GSM2152394 |
SVE + UGM, CAD104 |
| GSM2152395 |
PE + UGM, CAD105 |
| GSM2152396 |
PE + UGM, CAD106 |
| GSM2152397 |
PE + UGM, CAD107 |
| GSM2152398 |
PE + UGM, CAD108 |
| GSM2152399 |
SVE (mNKX3.1) + UGM, CAD109 |
| GSM2152400 |
SVE (mNKX3.1) + UGM, CAD110 |
| GSM2152401 |
SVE (mNKX3.1) + UGM, CAD111 |
| GSM2152402 |
SVE (mNKX3.1) + UGM, CAD112 |
| GSM2152403 |
SVE (UTY_sh) + UGM, CAD113 |
| GSM2152404 |
SVE (UTY_sh) + UGM, CAD114 |
| GSM2152405 |
SVE (UTY_sh) + UGM, CAD115 |
| GSM2152406 |
SVE (UTY_sh) + UGM, CAD116 |
| GSM2152407 |
SVE (mNKX3.1 + UTY_sh) + UGM, CAD117 |
| GSM2152408 |
SVE (mNKX3.1 + UTY_sh) + UGM, CAD118 |
| GSM2152409 |
SVE (mNKX3.1 + UTY_sh) + UGM, CAD119 |
| GSM2152410 |
SVE (mNKX3.1 + UTY_sh) + UGM, CAD120 |
| GSM2152526 |
RWPE1 - Control Vector, CAD1 |
| GSM2152527 |
RWPE1 - Control Vector, CAD2 |
| GSM2152528 |
RWPE1 - Control Vector, CAD3 |
| GSM2152529 |
RWPE1 - Control Vector, CAD4 |
| GSM2152530 |
RWPE1 - Control Vector, CAD5 |
| GSM2152531 |
RWPE1 - Control Vector, CAD6 |
| GSM2152532 |
RWPE1 - NKX3.1, CAD13 |
| GSM2152533 |
RWPE1 - NKX3.1, CAD14 |
| GSM2152534 |
RWPE1 - NKX3.1, CAD15 |
| GSM2152535 |
RWPE1 - NKX3.1, CAD16 |
| GSM2152536 |
RWPE1 - NKX3.1, CAD17 |
| GSM2152537 |
RWPE1 - NKX3.1, CAD18 |
| GSM2152538 |
RWPE1- NKX3.1 (T164A), CAD91 |
| GSM2152539 |
RWPE1- NKX3.1 (T164A), CAD92 |
| GSM2152540 |
RWPE1- NKX3.1 (T164A), CAD93 |
| GSM2152541 |
RWPE1- NKX3.1 (T164A), CAD94 |
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| This SuperSeries is composed of the following SubSeries:
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| GSE80600 |
Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_15M_SV_Affy) |
| GSE81424 |
Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_4M-Prostate_RNA-Seq) |
| GSE81432 |
Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_Recomb_RNA-Seq) |
| GSE81439 |
Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Human_RWPE1_RNA-Seq) |
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| Relations |
| BioProject |
PRJNA321537 |
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