NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE85920 Query DataSets for GSE85920
Status Public on Aug 23, 2016
Title APOL1 renal-risk variants induce mitochondrial dysfunction (Affymetrix 2)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To assess differential gene expression by APOL1 renal-risk (2 risk alleles) vs. non-risk (G0G0) genotypes in primary proximal tubule cells (PTCs), global gene expression (mRNA) levels were examined on Affymetrix HTA 2.0 arrays in primary PTCs cultured from non-diseased kidney in African Americans without CKD who underwent nephrectomy for localized renal cell carcinoma.
 
Overall design To detect differentially expressed gene profiles attributable to APOL1 renal-risk genotypes, African American primary proximal tubule cells with two APOL1 renal-risk alleles (N=5) and lacking renal-risk alleles (N=25) were included in comparisons of global gene expression.
 
Contributor(s) Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AA, Langefeld CD, Murea M, Parks JS, Freedman BI
Citation(s) 27821631
Submission date Aug 22, 2016
Last update date Oct 29, 2018
Contact name Lijun Ma
E-mail(s) lima@wakehealth.edu
Organization name Wake Forest School of Medicine
Department Nephrology
Street address 1 Medical Center Blvd
City Winston Salem
State/province NC
ZIP/Postal code 27157
Country USA
 
Platforms (1)
GPL17586 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Samples (30)
GSM2287828 African American primary proximal tubule cells K10015
GSM2287829 African American primary proximal tubule cells K10023
GSM2287830 African American primary proximal tubule cells K10053
This SubSeries is part of SuperSeries:
GSE85921 APOL1 renal-risk variants induce mitochondrial dysfunction
Relations
BioProject PRJNA339758

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85920_RAW.tar 690.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap