|
| Status |
Public on Feb 20, 2017 |
| Title |
Identification of hypoxia-induced HIF1A targets in melanocytes reveals a molecular profile associated with poor prognosis for melanoma [gene expression] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
These datasets describe a melanocyte specific, HIF1A-Dependent / Hypoxia-Responsive gene expression signature defined by the regulation of genes critical to metabolism, chromatin and transcriptional regulation, vascularization and cellular invasivness. These genes provide lineage specific targets for refinement of diagnostic markers associated with primary melanoma tumor metastatic potential, and also provides novel molecular targets for therapeutic strategies targeting metastatic disease progression.
|
| |
|
| Overall design |
Microarray gene expression analysis was performed in biological triplicate for each condition of immortal melanocyte cell line, melan Ink4a-Arf grown cells.
contributor: NISC Comparative Sequencing Program
|
| |
|
| Contributor(s) |
Loftus SK, Baxter LL, Cronin JC, Fufa TD, Pavan WJ |
| Citation(s) |
28168807 |
| |
| Submission date |
Sep 07, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Stacie Loftus |
| E-mail(s) |
sloftus@mail.nih.gov
|
| Phone |
301-594-1752
|
| Organization name |
National Human Genome Research Institute
|
| Street address |
49 Convent Dr
|
| City |
Bethesda |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (15)
|
|
| This SubSeries is part of SuperSeries: |
| GSE86555 |
Identification of hypoxia-induced HIF1A targets in melanocytes reveals a molecular profile associated with poor prognosis for melanoma |
|
| Relations |
| BioProject |
PRJNA342186 |
Less...
More...