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Series GSE88773 Query DataSets for GSE88773
Status Public on Jan 03, 2017
Title Networks of cultured iPSC-derived neurons reveal the human synaptic activity-regulated adaptive gene program
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We studied the synaptic activity-regulated gene expression response in the human genetic background using cultured human iPSC-derived (hiPSCd) neuronal networks and networks of hiPSCd neurons mixed with mouse primary neurons. Our results confirm that genetic changes affect the synaptic activity-regulated gene program, proposing a functional mechanism how they have driven evolution of human cognitive abilities.
 
Overall design We compared RNA profiles of untreated hiPSCd neurons and hiPSCd neurons treated with bicuculline and 4-aminopyridine for 1 or 4 hours. Samples were collected from hiPSCd neuron-only cultures and from co-cultures of hiPSCd neurons and mouse primary hippocampal neurons.
 
Contributor(s) Pruunsild P, Bengtson CP, Bading H
Citation(s) 28052243, 37019214
Submission date Oct 14, 2016
Last update date Aug 28, 2023
Contact name Priit Pruunsild
E-mail(s) pruunsild@nbio.uni-heidelberg.de
Organization name University of Heidelberg
Department Neurobiology
Street address INF 364
City Heidelberg
ZIP/Postal code 69120
Country Germany
 
Platforms (3)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL16512 Illumina HiSeq 2000 (Homo sapiens; Mus musculus)
GPL19415 Illumina NextSeq 500 (Homo sapiens; Mus musculus)
Samples (22)
GSM2345392 hiPSCd neuron-only untreated control Hs_CNTR_1
GSM2345393 hiPSCd neuron-only untreated control Hs_CNTR_2
GSM2345394 hiPSCd neuron-only untreated control Hs_CNTR_3
Relations
BioProject PRJNA348535
SRA SRP091573

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE88773_RAW.tar 2.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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