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Series GSE89827

Query DataSets for GSE89827

Status

Public on Jan 03, 2017

Title

Human Lacrimal Gland Gene Expression

Organism

Homo sapiens

Experiment type

Expression profiling by array
Third-party reanalysis

Summary

Background: The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis between lacrimal gland and other embryologically similar tissues may be helpful in furthering our understanding of lacrimal gland development. Methods: We performed global gene expression analysis of human lacrimal gland tissue using Affymetrix ® gene expression arrays. Primary data from our laboratory was compared with datasets available in the NLM GEO database for other surface ectodermal tissues including salivary gland, skin, conjunctiva and corneal epithelium. Results: The analysis revealed statistically significant difference in the gene expression of lacrimal gland tissue compared to other ectodermal tissues. The lacrimal gland specific, cell surface secretory protein encoding genes and critical signaling pathways which distinguish lacrimal gland from other ectodermal tissues are described. Conclusions: Differential gene expression in human lacrimal gland compared with other ectodermal tissue types revealed interesting patterns which may serve as the basis for future studies in directed differentiation among other areas.

Overall design

8 microarray samples co-analyzed with 104 publicly available microarray datasets

Contributor(s)

Kumar Aakalu V, Parmeswaran S, Maienschein-Cline M, Bahroos N, Shah D, Ali M, Subramanian K

Citation(s)

28081151

Submission date

Nov 14, 2016

Last update date

Oct 29, 2018

Contact name

Mark Maienschein-Cline

E-mail(s)

mmaiensc@uic.edu

Organization name

University of Illinois at Chicago

Department

Research Resources Center

Lab

Center for Research Informatics

Street address

1819 W Polk Ave, Rm 336 M/C 789

City

Chicago

State/province

ZIP/Postal code

60612

Country

USA

Platforms (2)

GPL6244	[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
GPL17586	[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]

Samples (8)

More...

GSM2390107	Main Lacrimal Gland1 right
GSM2390108	Main Lacrimal Gland1 left
GSM2390109	Main Lacrimal Gland2 right

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BioProject

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE89827_RAW.tar	146.7 Mb	(http)(custom)	TAR (of CEL)
GSE89827_Re-normalized-log2-RMA.txt.gz	6.7 Mb	(ftp)(http)	TXT
GSE89827_sample_list.xls.gz	9.0 Kb	(ftp)(http)	XLS
Processed data are available on Series record