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| Status |
Public on Jan 25, 2017 |
| Title |
Expression date from db/db mice with or without treatment of traditional Chinese medicine Tang-shen Formula |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The Chinese herbal granule Tangshen Formula (TSF) has been proven to decrease proteinuria and improve estimated glomerular filtration rate (eGFR) in diabetic kidney disease (DKD) patients with albuminuria. Nevertheless, little was known on the underlying mechanisms of TSF on treating DN.
We used microarrays to detail to explore the target genes of TSF in the treatment of DN.
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| Overall design |
Renal cortical tissues were selected from db/m mice, db/db mice and db/db mice with TSF-treatment for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain to identify the therapeutic target of TSF in diabetic renal injuries through microarray-based gene expression profiling.
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| Contributor(s) |
Li P, Zhao T, Zhang H, Yan M, Zhao H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 03, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Hailing Zhao |
| Organization name |
China–Japan Friendship Hospital
|
| Street address |
Yinghua DongLu Hepingli Chaoyang District
|
| City |
Beijing |
| ZIP/Postal code |
100029 |
| Country |
China |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| GSM2415029 |
kidney of db/db mice ,biological rep1 |
| GSM2415030 |
kidney of db/db mice ,biological rep2 |
| GSM2415031 |
kidney of db/db mice ,biological rep3 |
| GSM2415032 |
kidney of db/db mice with Tang-shen formula treatment,biological rep1 |
| GSM2415033 |
kidney of db/db mice with Tang-shen formula treatment,biological rep2 |
| GSM2415034 |
kidney of db/db mice with Tang-shen formula treatment,biological rep3 |
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| Relations |
| BioProject |
PRJNA356125 |
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