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| Status |
Public on Jan 01, 2018 |
| Title |
Targeting ribonucleotide reductase by 3-AP in primary effusion lymphoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
KSHV is a principal causative agent of primary effusion lymphoma (PEL) which is lacking of effective treatment. Our previous data have showed that HGF/c-MET pathway is highly active within KSHV+ PEL cells and plays important role in tumor cell survival/growth. By using microarray analysis, we have identified the global gene profile controlled by HGF/c-MET pathway within KSHV+ PEL cell-lines and several novel “druggable” candidates closely related to cancer cell survival/growth, including ribonucleotide reductase (RR). We continue to use microarray analysis to identify the gene profile affected within PEL cells exposure to RR inhibitor, 3-AP.
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| |
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| Overall design |
PEL cells were treated with vehicle control or RR inhibitor 3-AP (2.5 µM) for 48 h, and the gene expression signature was compared to respective vehicle controls
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| |
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| Contributor(s) |
Dai L, Zabaleta J, Qin Z |
| Citation(s) |
28459467 |
| |
| Submission date |
Dec 09, 2016 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Zhiqiang Qin |
| E-mail(s) |
zqin@lsuhsc.edu
|
| Organization name |
LSUHSC-NO
|
| Street address |
1700 Tulane Ave
|
| City |
New Orleans |
| State/province |
LA |
| ZIP/Postal code |
70112 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA357028 |
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