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| Status |
Public on Nov 07, 2007 |
| Title |
Expression data from adult rat testes treated with 3 mg/kg b.w. cadmium chloride via i.p. |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
This is a study to explore the transcriptional changes after cadmium treatment in adult rat testes at three time points (control--0 hour, 8 hour and 4 day). Cadmium is an environmental toxicant that is known to affect the male reproductive system. It disrupts the blood-testis barrier irreversibly, and affects the Sertoli-germ cells adhesion, causing germ cell depletion from the seminiferous epithelium.
Keywords: Cadmium effect in rat testes
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| Overall design |
Adult Sprague-Dawley rats treated with a single dose of cadmium chloride at 3 mg/kg b.w. by i.p. and terminated after 8 hours (n=2) and 20 hours (n=2). Testes from cadmium-treated rats and untreated (control, 0 hour, n=3) rats were harvested and total RNA were prepared. Standard Affymetrix genechip procedures were followed for the subsequent experiments. Data were analysed in MAS 5.0 and GeneSpring 7.2.
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| Contributor(s) |
Xia W, Cheng CY |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 31, 2007 |
| Last update date |
Jul 31, 2017 |
| Contact name |
C YAN CHENG |
| E-mail(s) |
yan@popcbr.rockefeller.edu
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| Phone |
212-327-8738
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| Fax |
212-327-8733
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| Organization name |
POPULATION COUNCIL
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| Street address |
1230 YORK AVENUE
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| City |
NEW YORK |
| State/province |
NY |
| ZIP/Postal code |
10021 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (7)
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| GSM240633 |
Testes, 8 hours after cadmium treatment, biological rep 1 |
| GSM240634 |
Testes, 8 hours after cadmium treatment, biological rep 2 |
| GSM240635 |
Testes, 20 hours after cadmium treatment, biological rep 1 |
| GSM240636 |
Testes, 20 hours after cadmium treatment, biological rep 2 |
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| Relations |
| BioProject |
PRJNA103255 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE9480_RAW.tar |
30.4 Mb |
(http)(custom) |
TAR (of CEL, EXP) |
| Processed data included within Sample table |
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