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    CD8B CD8 subunit beta [ Homo sapiens (human) ]

    Gene ID: 926, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CD8Bprovided by HGNC
    Official Full Name
    CD8 subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:1707
    See related
    Ensembl:ENSG00000172116 MIM:186730; AllianceGenome:HGNC:1707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LY3; P37; LEU2; LYT3; Ly-3; CD8B1; CD8beta
    Summary
    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
    Expression
    Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD8B in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (86815369..86861886, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (86817280..86863804, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87042492..87089009, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr2:86947334-86947492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86952106-86952606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86952607-86953107 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16165 Neighboring gene CD8A intronic regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:87016737-87017571 Neighboring gene uncharacterized LOC105374846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11721 Neighboring gene MPRA-validated peak3783 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87066785-87067341 Neighboring gene CD8 subunit alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083199-87083700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083701-87084200 Neighboring gene ANAPC1 pseudogene 1 Neighboring gene RANBP2 like and GRIP domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 5 Neighboring gene WBP1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A second chain of human CD8 is expressed on peripheral blood lymphocytes. Shiue L, et al. J Exp Med, 1988 Dec 1. PMID 3264320, Free PMC Article
    2. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, et al. J Immunol, 2008 Jun 1. PMID 18490743
    3. Differential expression and regulation of the human CD8 alpha and CD8 beta chains. Terry LA, et al. Tissue Antigens, 1990 Feb. PMID 2111591
    4. CD8B, the human equivalent of the mouse Ly-3 gene is localized on chromosome 2. Spurr NK, et al. Immunogenetics, 1988. PMID 3257101
    5. The human Lyt-3 molecule requires CD8 for cell surface expression. DiSanto JP, et al. EMBO J, 1988 Nov. PMID 3145196, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
      Title: Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
    2. CD45RA, CD8beta, and IFNgamma Are Potential Immune Biomarkers of Human Cognitive Function.
      Title: CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function.
    3. results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored
      Title: Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2.
    4. Endometrioid endometrial carcinomas are capable of down-regulating CD8 expression by cytotoxic T lymphocytes.
      Title: CD8 down-regulation on cytotoxic T lymphocytes of patients with endometrioid endometrial carcinomas.
    5. CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
      Title: cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
    6. transcription factor cAMP-responsive element modulator alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A and CD8B.
      Title: cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.
    7. Nef-mediated down-modulation of CD8alphabeta is a fundamental property of primate lentiviruses.
      Title: Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.
    8. [review] Coreceptor CD8alphabeta contributes to the antigen-recognition process by binding to a largely invariant region of the MHCI molecule and by promoting intracellular signaling.
      Title: The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Data show that CD8+LAP+ cells produce IFN-gamma, and these cells suppress EAE that is dependent on both TGF-beta and IFN-gamma.
      Title: Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    Nef nef HIV-1 Nef downregulates surface expression of the beta-chain of the CD8 receptor by accelerated endocytosis; amino acid positions 57 to 58 and 174 to 175 in Nef are involved in the down modulation PubMed
    nef HIV-1 Nef interaction with AP-1gamma is required for CD28 and CD8beta downregulation PubMed
    nef Downregulation of CD8beta by HIV-1 Nef requires an intact AP-2 complex PubMed
    nef Co-localization of HIV-1 Nef and CD8beta is revealed by staining assays in 293T cells expressing both proteins PubMed
    Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class I protein binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables coreceptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in T cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adaptive immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of T cell receptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD8 beta chain
    Names
    CD8 antigen, beta polypeptide 1 (p37)
    CD8b molecule
    Ly-3 homolog
    T lymphocyte surface glycoprotein beta chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178100.2 → NP_001171571.1  T-cell surface glycoprotein CD8 beta chain isoform 6 precursor

      See identical proteins and their annotated locations for NP_001171571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two exons in the 3' coding region, which results in a frameshift, compared to variant 2. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AW296309, BC100912, DC405359, X13445
      Consensus CDS
      CCDS54376.1
      UniProtKB/TrEMBL
      Q9UQ56
      Related
      ENSP00000377358.2, ENST00000393761.6
      Conserved Domains (2) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26 → 134
      IG_like; Immunoglobulin like

    2. NM_004931.5 → NP_004922.1  T-cell surface glycoprotein CD8 beta chain isoform 5 precursor

      See identical proteins and their annotated locations for NP_004922.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as M-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AC111200, BC100912, BP392114, DB223179, DC405359, X13444
      Consensus CDS
      CCDS1997.1
      UniProtKB/Swiss-Prot
      P10966, P14860, P14861, Q15980, Q496E0, Q496E1, Q496E2, Q9UDB4, Q9UDB5, Q9UDB6, Q9UDB7, Q9UDB8, Q9UDB9, Q9UDC0, Q9UQ55
      UniProtKB/TrEMBL
      E9PD41
      Related
      ENSP00000375070.6, ENST00000390655.12
      Conserved Domains (2) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26 → 134
      IG_like; Immunoglobulin like

    3. NM_172101.5 → NP_742099.1  T-cell surface glycoprotein CD8 beta chain isoform 3 precursor

      See identical proteins and their annotated locations for NP_742099.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as M-3, includes an alternate exon in the 3' coding region, which results in a frameshift compared to variant 2. The resulting membrane associated protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AW296309, BC100912, DC405359, X13445
      Consensus CDS
      CCDS42708.1
      UniProtKB/TrEMBL
      B4E0F8, E7EPH5
      Related
      ENSP00000377356.2, ENST00000393759.6
      Conserved Domains (2) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26 → 134
      IG_like; Immunoglobulin like

    4. NM_172102.5 → NP_742100.1  T-cell surface glycoprotein CD8 beta chain isoform 4 precursor

      See identical proteins and their annotated locations for NP_742100.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as S-1, lacks an in-frame exon in the coding region, compared to variant 2. The resulting secreted protein (isoform 4) is shorter than isoform 2.
      Source sequence(s)
      AW296309, BC100912, DC405359, X13446
      Consensus CDS
      CCDS1994.1
      UniProtKB/TrEMBL
      B4E0F8, E7EPH5
      Related
      ENSP00000340592.3, ENST00000349455.7
      Conserved Domains (2) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26 → 134
      IG_like; Immunoglobulin like

    5. NM_172213.5 → NP_757362.1  T-cell surface glycoprotein CD8 beta chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_757362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AW296309, BC100912, BC100913, DC405359
      Consensus CDS
      CCDS1995.1
      UniProtKB/TrEMBL
      B4E0F8, E7EPH5
      Related
      ENSP00000331172.2, ENST00000331469.6
      Conserved Domains (1) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      86815369..86861886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533164.3 → XP_011531466.1  T-cell surface glycoprotein CD8 beta chain isoform X1

      See identical proteins and their annotated locations for XP_011531466.1

      UniProtKB/TrEMBL
      B4E0F8, E7EPH5, E9PD41, Q53QL8
      Conserved Domains (2) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
      smart00410
      Location:26 → 134
      IG_like; Immunoglobulin like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      86817280..86863804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344557.1 → XP_054200532.1  T-cell surface glycoprotein CD8 beta chain isoform X1

      UniProtKB/TrEMBL
      Q53QL8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172099.2: Suppressed sequence

      Description
      NM_172099.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

    2. NM_172100.1: Suppressed sequence

      Description
      NM_172100.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10966.1 GenPept UniProtKB/Swiss-Prot:P10966

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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