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    egr2a early growth response 2a [ Danio rerio (zebrafish) ]

    Gene ID: 368241, updated on 19-Jun-2024

    Summary

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    Official Symbol
    egr2aprovided by ZNC
    Official Full Name
    early growth response 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030723-6
    See related
    Ensembl:ENSDARG00000044098 AllianceGenome:ZFIN:ZDB-GENE-030723-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    frb35
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hindbrain and hindbrain neural keel. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See egr2a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43663486..43677754, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43672955..43675628, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 365 Neighboring gene 2-aminoethanethiol (cysteamine) dioxygenase b Neighboring gene nuclear receptor binding factor 2a Neighboring gene jumonji domain containing 1Ca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Sun Z, et al. Mech Dev, 2002 Jun. PMID 12175499
    2. Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation. Voltes A, et al. Development, 2019 Jul 22. PMID 31273051
    3. Peripheral axons of the adult zebrafish maxillary barbel extensively remyelinate during sensory appendage regeneration. Moore AC, et al. J Comp Neurol, 2012 Dec 15. PMID 22592645, Free PMC Article
    4. Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages. Wang H, et al. Chemosphere, 2019 Apr. PMID 33395817
    5. Zinc finger protein 365 is a new maternal LPS-binding protein that defends zebrafish embryos against gram-negative bacterial infections. Du X, et al. FASEB J, 2018 Feb. PMID 29042450

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish gene frb35 encodes a novel zinc finger protein that shares a high homology with Krx-20; the expression domains of frb35 overlap those of krx-20
      Title: A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase EGR2a; early growth response 2a
    Names
    krox-20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328404.2 → NP_001315333.1  E3 SUMO-protein ligase EGR2a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BX927349
      UniProtKB/TrEMBL
      A0A8M1P4S0, E7F266
      Related
      ENSDARP00000072456.5, ENSDART00000077990.6
      Conserved Domains (4) summary
      COG5048
      Location:321 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:293 → 317
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:337 → 362
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001359896.1 → NP_001346825.1  E3 SUMO-protein ligase EGR2a isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX927349
      UniProtKB/TrEMBL
      A0A8M9PE40
      Conserved Domains (4) summary
      COG5048
      Location:319 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:291 → 315
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:89 → 154
      DUF3446; Domain of unknown function (DUF3446)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      43663486..43677754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467119.1 → XP_021322794.1  early growth response 2a isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:319 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:291 → 315
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:89 → 154
      DUF3446; Domain of unknown function (DUF3446)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183341.1: Suppressed sequence

      Description
      NM_183341.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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