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    PFKM phosphofructokinase, muscle [ Homo sapiens (human) ]

    Gene ID: 5213, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PFKMprovided by HGNC
    Official Full Name
    phosphofructokinase, muscleprovided by HGNC
    Primary source
    HGNC:HGNC:8877
    See related
    Ensembl:ENSG00000152556 MIM:610681; AllianceGenome:HGNC:8877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
    Summary
    Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
    Expression
    Broad expression in heart (RPKM 77.2), brain (RPKM 32.0) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PFKM in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48105353..48146404)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48066690..48107749)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48499136..48540187)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 1 Neighboring gene V-type proton ATPase subunit F-like Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr12:48484832-48485048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48498859-48499734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48499735-48500608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6279 Neighboring gene microRNA 6505 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48536214-48537195 Neighboring gene NANOG hESC enhancer GRCh37_chr12:48551082-48551604 Neighboring gene SCO1 cytochrome c oxidase assembly protein pseudogene Neighboring gene ankyrin repeat and SOCS box containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population. Long S, et al. Pediatr Surg Int, 2022 Sep. PMID 35838787
    2. Evolution of allosteric citrate binding sites on 6-phosphofructo-1-kinase. Usenik A, et al. PLoS One, 2010 Nov 23. PMID 21124851, Free PMC Article
    3. Cloning and expression of a human muscle phosphofructokinase cDNA. Sharma PM, et al. Gene, 1989 Apr 15. PMID 2526045
    4. Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells. Zancan P, et al. Mol Genet Metab, 2010 Aug. PMID 20483646
    5. Deficiency of phosphofructo-1-kinase/muscle subtype in humans impairs insulin secretion and causes insulin resistance. Ristow M, et al. J Clin Invest, 1997 Dec 1. PMID 9389749, Free PMC Article

    See all (159) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.
      Title: Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.
    2. RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells.
      Title: RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells.
    3. Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.
      Title: Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.
    4. Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.
      Title: Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.
    5. Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.
      Title: Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.
    6. RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.
      Title: RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.
    7. PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.
      Title: PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.
    8. TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
      Title: TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
    9. ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.
      Title: ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.
    10. Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
      Title: Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Glycogen storage disease, type VII
    MedGen: C0017926 OMIM: 232800 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of phosphofructokinase (muscle, PFKM) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8699

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 6-phosphofructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 6-phosphofructokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 6-phosphofructokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose-6-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical glycolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fructose 6-phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolysis from storage polysaccharide through glucose-1-phosphate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process through fructose-6-phosphate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 6-phosphofructokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of 6-phosphofructokinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm principal piece IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent 6-phosphofructokinase, muscle type
    Names
    6-phosphofructo-1-kinase
    6-phosphofructokinase type A
    6-phosphofructokinase, muscle type
    phosphofructo-1-kinase isozyme A
    phosphofructokinase 1
    phosphofructokinase, polypeptide X
    phosphofructokinase-M
    phosphohexokinase
    protein phosphatase 1, regulatory subunit 122
    NP_000280.1
    NP_001160158.1
    NP_001160159.1
    NP_001160160.1
    NP_001341664.1
    NP_001341665.1
    NP_001341666.1
    NP_001341667.1
    NP_001341668.1
    NP_001341669.1
    NP_001341670.1
    NP_001341671.1
    NP_001341672.1
    NP_001341673.1
    NP_001341674.1
    NP_001341675.1
    NP_001341676.1
    NP_001341677.1
    NP_001350548.1
    XP_005269031.1
    XP_005269033.1
    XP_011536789.2
    XP_016874958.1
    XP_024304788.1
    XP_024304789.1
    XP_024304790.1
    XP_047284955.1
    XP_047284956.1
    XP_047284957.1
    XP_047284958.1
    XP_047284959.1
    XP_047284960.1
    XP_054228244.1
    XP_054228245.1
    XP_054228246.1
    XP_054228247.1
    XP_054228248.1
    XP_054228249.1
    XP_054228250.1
    XP_054228251.1
    XP_054228252.1
    XP_054228253.1
    XP_054228254.1
    XP_054228255.1
    XP_054228256.1
    XP_054228257.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016199.2 RefSeqGene

      Range
      19112..46152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1177

    mRNA and Protein(s)

    1. NM_000289.6 → NP_000280.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

      See identical proteins and their annotated locations for NP_000280.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as type C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
      Source sequence(s)
      BC000534, BC021203, BU683561, DA525437
      Consensus CDS
      CCDS8760.1
      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5, Q96I60
      Related
      ENSP00000352842.5, ENST00000359794.11
      Conserved Domains (1) summary
      cd00764
      Location:13 → 774
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    2. NM_001166686.2 → NP_001160158.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

      See identical proteins and their annotated locations for NP_001160158.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) (also known as TE-PFKM) encodes isoform 1. Variants 1, 7, 8, and 9 encode the same isoform (1).
      Source sequence(s)
      BC000534, BC021203, BU683561, DB081387
      Consensus CDS
      CCDS53786.1
      UniProtKB/TrEMBL
      Q96I60
      Related
      ENSP00000345771.6, ENST00000340802.12
      Conserved Domains (1) summary
      cd00764
      Location:84 → 845
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    3. NM_001166687.2 → NP_001160159.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

      See identical proteins and their annotated locations for NP_001160159.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as type A) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
      Source sequence(s)
      BC000534, BU683561, DA560355, Y00698
      Consensus CDS
      CCDS8760.1
      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5, Q96I60
      Related
      ENSP00000309438.7, ENST00000312352.11
      Conserved Domains (1) summary
      cd00764
      Location:13 → 774
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    4. NM_001166688.2 → NP_001160160.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

      See identical proteins and their annotated locations for NP_001160160.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as type B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
      Source sequence(s)
      BC000534, BU683561, DA761651
      Consensus CDS
      CCDS8760.1
      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5, Q96I60
      Related
      ENSP00000449426.1, ENST00000547587.5
      Conserved Domains (1) summary
      cd00764
      Location:13 → 774
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    5. NM_001354735.1 → NP_001341664.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS86294.1
      UniProtKB/TrEMBL
      A0A2R8Y891, Q96I60
      Related
      ENSP00000496597.1, ENST00000642730.1
      Conserved Domains (1) summary
      cd00764
      Location:116 → 877
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    6. NM_001354736.1 → NP_001341665.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS86294.1
      UniProtKB/TrEMBL
      A0A2R8Y891, Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:116 → 877
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    7. NM_001354737.1 → NP_001341666.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS53786.1
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:84 → 845
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    8. NM_001354738.1 → NP_001341667.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS53786.1
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:84 → 845
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    9. NM_001354739.1 → NP_001341668.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS53786.1
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:84 → 845
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    10. NM_001354740.1 → NP_001341669.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:61 → 822
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    11. NM_001354741.2 → NP_001341670.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:21 → 782
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    12. NM_001354742.2 → NP_001341671.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS8760.1
      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5, Q96I60
      Related
      ENSP00000450369.2, ENST00000550345.6
      Conserved Domains (1) summary
      cd00764
      Location:13 → 774
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    13. NM_001354743.2 → NP_001341672.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS8760.1
      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5, Q96I60
      Related
      ENSP00000446945.2, ENST00000550924.6
      Conserved Domains (1) summary
      cd00764
      Location:13 → 774
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    14. NM_001354744.2 → NP_001341673.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      Consensus CDS
      CCDS8760.1
      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5, Q96I60
      Related
      ENSP00000448253.2, ENST00000551339.6
      Conserved Domains (1) summary
      cd00764
      Location:13 → 774
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    15. NM_001354745.2 → NP_001341674.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:1 → 745
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    16. NM_001354746.2 → NP_001341675.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:13 → 732
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    17. NM_001354747.2 → NP_001341676.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:3 → 724
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    18. NM_001354748.2 → NP_001341677.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029
      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:3 → 724
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    19. NM_001363619.2 → NP_001350548.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029, KU178252
      Consensus CDS
      CCDS86295.1
      UniProtKB/TrEMBL
      A0A0S2Z4I1, Q96I60
      Related
      ENSP00000448177.1, ENST00000551804.5
      Conserved Domains (1) summary
      cd00764
      Location:13 → 743
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    RNA

    1. NR_148954.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029, U24183
      Related
      ENST00000546964.5

    2. NR_148955.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029, AK126020
      Related
      ENST00000547581.5

    3. NR_148956.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029

    4. NR_148957.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029

    5. NR_148958.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029

    6. NR_148959.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004801, AC074029

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48105353..48146404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428999.1 → XP_047284955.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X1

    2. XM_011538487.2 → XP_011536789.2  ATP-dependent 6-phosphofructokinase, muscle type isoform X2

    3. XM_047429000.1 → XP_047284956.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X3

    4. XM_005268976.4 → XP_005269033.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

      See identical proteins and their annotated locations for XP_005269033.1

      UniProtKB/TrEMBL
      A0A2R8Y891, Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:116 → 877
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    5. XM_047429001.1 → XP_047284957.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X4

    6. XM_024449020.2 → XP_024304788.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X6

      UniProtKB/TrEMBL
      F8VTQ3, Q96I60
      Related
      ENSP00000447997.3, ENST00000550257.7
      Conserved Domains (1) summary
      cd00764
      Location:87 → 848
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    7. XM_047429002.1 → XP_047284958.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X7

    8. XM_024449021.2 → XP_024304789.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X9

      UniProtKB/TrEMBL
      Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:46 → 807
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    9. XM_047429004.1 → XP_047284960.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X11

      Related
      ENSP00000446829.3, ENST00000549941.7

    10. XM_017019469.2 → XP_016874958.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X8

      UniProtKB/TrEMBL
      Q96I60

    11. XM_005268974.2 → XP_005269031.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

      See identical proteins and their annotated locations for XP_005269031.1

      UniProtKB/TrEMBL
      A0A2R8Y891, Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:116 → 877
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    12. XM_047429003.1 → XP_047284959.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X10

    13. XM_024449022.2 → XP_024304790.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X12

      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5, Q96I60
      Conserved Domains (1) summary
      cd00764
      Location:13 → 774
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48066690..48107749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372275.1 → XP_054228250.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X14

    2. XM_054372271.1 → XP_054228246.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

    3. XM_054372269.1 → XP_054228244.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X4

    4. XM_054372272.1 → XP_054228247.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X13

    5. XM_054372273.1 → XP_054228248.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X6

      UniProtKB/TrEMBL
      F8VTQ3

    6. XM_054372276.1 → XP_054228251.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X7

    7. XM_054372279.1 → XP_054228254.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X9

    8. XM_054372281.1 → XP_054228256.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X11

    9. XM_054372277.1 → XP_054228252.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X8

    10. XM_054372270.1 → XP_054228245.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

    11. XM_054372274.1 → XP_054228249.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X14

    12. XM_054372278.1 → XP_054228253.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X8

    13. XM_054372280.1 → XP_054228255.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X10

    14. XM_054372282.1 → XP_054228257.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X12

      UniProtKB/Swiss-Prot
      J3KNX3, P08237, Q16814, Q16815, Q6ZTT1
      UniProtKB/TrEMBL
      A0A024R0Y5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08237.2 GenPept UniProtKB/Swiss-Prot:P08237

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