Multiple endocrine neoplasia, type 1
- Synonyms
- Endocrine adenomatosis multiple; MEA I; MEN 1; MEN I; Wermer syndrome
- Modes of inheritance
- Autosomal dominant inheritance (Orphanet)
Not genetically inherited (Orphanet)
Summary
Excerpted from the GeneReview:- Full text of GeneReview (by section):
- Summary
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- Chapter Notes
- References
- Authors:
- Francesca Giusti
- Francesca Marini
- Maria Luisa Brandi
- view full author information
Available tests
Check Related conditions for additional relevant tests.
Clinical tests (136 available)
Clinical features
Help- Abnormality of head or neck
- Adenoma sebaceum
Adenoma sebaceum
- MedGen UID: 75563
- Concept ID: C0265319
- Finding: Neoplastic Process
Abnormality of head or neck
- Adenoma sebaceum
- Abnormality of metabolism/homeostasis
- Hypercalcemia
Hypercalcemia
- MedGen UID: 5686
- Concept ID: C0020437
- Finding: Disease or Syndrome
Abnormality of metabolism/homeostasis
- Hypoglycemia
Hypoglycemia
- MedGen UID: 6979
- Concept ID: C0020615
- Finding: Disease or Syndrome
Abnormality of metabolism/homeostasis
- Hypercalcemia
- Abnormality of the digestive system
- Diarrhea
Diarrhea
- MedGen UID: 8360
- Concept ID: C0011991
- Finding: Sign or Symptom
Abnormality of the digestive system
- Esophagitis
Esophagitis
- MedGen UID: 4549
- Concept ID: C0014868
- Finding: Disease or Syndrome
Abnormality of the digestive system
- Peptic ulcer
Peptic ulcer
- MedGen UID: 45384
- Concept ID: C0030920
- Finding: Disease or Syndrome
Abnormality of the digestive system
- Zollinger-Ellison syndrome
Zollinger-Ellison syndrome
- MedGen UID: 53129
- Concept ID: C0043515
- Finding: Disease or Syndrome
Abnormality of the digestive system
- Diarrhea
- Abnormality of the endocrine system
- Elevated circulating growth hormone concentration
Elevated circulating growth hormone concentration
- MedGen UID: 66732
- Concept ID: C0235986
- Finding: Finding
Abnormality of the endocrine system
- Increased circulating cortisol level
Increased circulating cortisol level
- MedGen UID: 871175
- Concept ID: C4025651
- Finding: Finding
Abnormality of the endocrine system
- Elevated circulating growth hormone concentration
- Abnormality of the integument
- Cafe-au-lait spot
Cafe-au-lait spot
- MedGen UID: 113157
- Concept ID: C0221263
- Finding: Finding
Abnormality of the integument
- Confetti-like hypopigmented macules
Confetti-like hypopigmented macules
- MedGen UID: 377093
- Concept ID: C1851705
- Finding: Finding
Abnormality of the integument
- Cafe-au-lait spot
- Abnormality of the nervous system
- Increased circulating prolactin concentration
Increased circulating prolactin concentration
- MedGen UID: 1702649
- Concept ID: C5200994
- Finding: Finding
Abnormality of the nervous system
- Increased circulating prolactin concentration
- Neoplasm
- Adrenocortical adenoma
Adrenocortical adenoma
- MedGen UID: 61654
- Concept ID: C0206667
- Finding: Neoplastic Process
Neoplasm
- Carcinoid tumor
Carcinoid tumor
- MedGen UID: 2838
- Concept ID: C0007095
- Finding: Neoplastic Process
Neoplasm
- Glucagonoma syndrome
Glucagonoma syndrome
- MedGen UID: 4908
- Concept ID: C0017689
- Finding: Neoplastic Process
Neoplasm
- Pancreatic insulinoma
Pancreatic insulinoma
- MedGen UID: 43907
- Concept ID: C0021670
- Finding: Neoplastic Process
Neoplasm
- Pancreatic islet cell adenoma
Pancreatic islet cell adenoma
- MedGen UID: 342066
- Concept ID: C1851697
- Finding: Neoplastic Process
Neoplasm
- Parathyroid gland adenoma
Parathyroid gland adenoma
- MedGen UID: 75502
- Concept ID: C0262587
- Finding: Neoplastic Process
Neoplasm
- Pituitary adenoma
Pituitary adenoma
- MedGen UID: 45933
- Concept ID: C0032000
- Finding: Neoplastic Process
Neoplasm
- Prolactin-producing pituitary gland adenoma
Prolactin-producing pituitary gland adenoma
- MedGen UID: 10936
- Concept ID: C0033375
- Finding: Neoplastic Process
Neoplasm
- Subcutaneous lipoma
Subcutaneous lipoma
- MedGen UID: 234674
- Concept ID: C1403035
- Finding: Neoplastic Process
Neoplasm
- Thyroid adenoma
Thyroid adenoma
- MedGen UID: 56228
- Concept ID: C0151468
- Finding: Neoplastic Process
Neoplasm
- Adrenocortical adenoma
- NCI PDQ, Cancer Genetics CounselingCancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version
- NCI PDQ, Endocrine and Neuroendocrine Neoplasia geneticsGenetics of Endocrine and Neuroendocrine Neoplasias (PDQ®): Health Professional Version
- NCI PDQ, Breast and Gynecologic CancersGenetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version
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