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Malignant tumor of floor of mouth

MedGen UID:
102264
•Concept ID:
C0153368
•
Neoplastic Process
Synonyms: CA - Cancer of floor of mouth; Cancer of floor of mouth; cancer of mouth floor; FOM - Cancer of floor of mouth; FOM - Malignant tumor of floor of mouth; Malignant Floor of Mouth Neoplasm; malignant floor of mouth neoplasm; Malignant Floor of Mouth Tumor; malignant floor of mouth tumor; malignant floor of mouth tumour; Malignant Floor of the Mouth Neoplasm; malignant floor of the mouth neoplasm; Malignant Floor of the Mouth Tumor; malignant floor of the mouth tumor; malignant floor of the mouth tumour; malignant mouth floor neoplasm; Malignant neoplasm of floor of mouth; Malignant Neoplasm of Floor of Mouth; malignant neoplasm of floor of mouth; malignant neoplasm of mouth floor; Malignant Neoplasm of the Floor of the Mouth; malignant neoplasm of the floor of the mouth; Malignant Tumor of Floor of Mouth; malignant tumor of floor of mouth; Malignant Tumor of the Floor of the Mouth; malignant tumor of the floor of the mouth; malignant tumour of the floor of the mouth; mouth floor cancer
SNOMED CT: FOM - Malignant tumor of floor of mouth (363385007); FOM - Cancer of floor of mouth (363385007); Cancer of floor of mouth (363385007); CA - Cancer of floor of mouth (363385007); Malignant neoplasm of floor of mouth (363385007); Malignant tumor of floor of mouth (363385007)
 
Monarch Initiative: MONDO:0021320

Definition

A primary or metastatic malignant neoplasm that affects the floor of the mouth. The majority of cases are carcinomas. [from NCI]

Professional guidelines

PubMed

Psychosocial Oncology: Optimizing Outcomes through Interdisciplinary Care in Head and Neck Oncology.
Henry M
Curr Oncol 2023 Jul 19;30(7):6859-6861. doi: 10.3390/curroncol30070501. PMID: 37504361Free PMC Article
Management of Mucoceles, Sialoceles, and Ranulas.
Bowers EMR, Schaitkin B
Otolaryngol Clin North Am 2021 Jun;54(3):543-551. doi: 10.1016/j.otc.2021.03.002. PMID: 34024482
Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival.
Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY
Am J Surg Pathol 2005 Feb;29(2):167-78. doi: 10.1097/01.pas.0000149687.90710.21. PMID: 15644773

Recent clinical studies

Etiology

Diagnosis and management of hypoglossal nerve-derived schwannoma in the floor of mouth: a case series.
Zhong J, Zhou Z, Hu Y, Zhao T, Yao Y, Zhong L, Zhu D
BMC Oral Health 2022 Jun 29;22(1):265. doi: 10.1186/s12903-022-02302-2. PMID: 35768820Free PMC Article
Patient-Reported Outcomes of Split-Thickness Skin Grafts for Floor of Mouth Cancer Reconstruction.
Larson AR, Han M, Webb KL, Ochoa E, Stanford-Moore G, El-Sayed IH, George JR, Ha PK, Heaton CM, Ryan WR
ORL J Otorhinolaryngol Relat Spec 2021;83(3):151-158. Epub 2021 Feb 12 doi: 10.1159/000512085. PMID: 33582667
Diagnosis and management of congenital floor of mouth masses: A systematic review.
Lucas JP, Allen M, Siegel B, Gonik N
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110541. Epub 2020 Dec 1 doi: 10.1016/j.ijporl.2020.110541. PMID: 33296834
Operative tactics in floor of mouth and tongue cancer resection - the importance of imaging and planning.
McMahon J, Steele P, Kyzas P, Pollard C, Jampana R, MacIver C, Subramaniam S, Devine J, Wales C, McCaul J
Br J Oral Maxillofac Surg 2021 Jan;59(1):5-15. Epub 2020 Oct 4 doi: 10.1016/j.bjoms.2020.08.118. PMID: 33143945
Congenital ranula.
Licéaga R, González C, Licéaga C, Vargas G
J Clin Pediatr Dent 2010 Spring;34(3):263-6. doi: 10.17796/jcpd.34.3.n3t6x8148g1756vl. PMID: 20578666

Diagnosis

Craniofacial Epidermoid and Dermoid Cysts.
Oh HJ, Eo MY, Sodnom-Ish B, Amponsah EK, Frimpong P, Myoung H, Kim SM
J Craniofac Surg 2023 Nov-Dec 01;34(8):2405-2409. Epub 2023 Jul 24 doi: 10.1097/SCS.0000000000009561. PMID: 37487139Free PMC Article
Pleomorphic adenoma of hard palate: a case report.
Yousra Z, Saliha C
Pan Afr Med J 2021;38:146. Epub 2021 Feb 9 doi: 10.11604/pamj.2021.38.146.26508. PMID: 33912316Free PMC Article
Congenital ranula.
Licéaga R, González C, Licéaga C, Vargas G
J Clin Pediatr Dent 2010 Spring;34(3):263-6. doi: 10.17796/jcpd.34.3.n3t6x8148g1756vl. PMID: 20578666
Oral cavity cancer.
Kirsch C
Top Magn Reson Imaging 2007 Aug;18(4):269-80. doi: 10.1097/RMR.0b013e3181572caa. PMID: 17893592
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Prediction of Speech, Swallowing, and Quality of Life in Oral Cavity Cancer Patients: A Pilot Study.
Bulbul MG, Wu M, Lin D, Emerick K, Deschler D, Richmon J, Goldsmith T, Zenga J, Puram SV, Varvares MA
Laryngoscope 2021 Nov;131(11):2497-2504. Epub 2021 Apr 21 doi: 10.1002/lary.29573. PMID: 33881173
Oral graft-versus-host disease.
Kuten-Shorrer M, Woo SB, Treister NS
Dent Clin North Am 2014 Apr;58(2):351-68. doi: 10.1016/j.cden.2013.12.007. PMID: 24655527
Natural history of potentially malignant oral lesions and conditions: an overview of the literature.
Napier SS, Speight PM
J Oral Pathol Med 2008 Jan;37(1):1-10. doi: 10.1111/j.1600-0714.2007.00579.x. PMID: 18154571
Oral leukoplakia: a clinicopathological review.
van der Waal I, Schepman KP, van der Meij EH, Smeele LE
Oral Oncol 1997 Sep;33(5):291-301. doi: 10.1016/s1368-8375(97)00002-x. PMID: 9415326

Prognosis

Survival analysis of age-related oral squamous cell carcinoma: a population study based on SEER.
Yang J, Guo K, Zhang A, Zhu Y, Li W, Yu J, Wang P
Eur J Med Res 2023 Oct 10;28(1):413. doi: 10.1186/s40001-023-01345-7. PMID: 37814268Free PMC Article
Diagnosis and management of congenital floor of mouth masses: A systematic review.
Lucas JP, Allen M, Siegel B, Gonik N
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110541. Epub 2020 Dec 1 doi: 10.1016/j.ijporl.2020.110541. PMID: 33296834
Results of postoperative interstitial brachytherapy of resectable floor of mouth tumors.
Ferenczi Ö, Major T, Akiyama H, Fröhlich G, Oberna F, Révész M, Poósz M, Polgár C, Takácsi-Nagy Z
Brachytherapy 2021 Mar-Apr;20(2):376-382. Epub 2020 Nov 26 doi: 10.1016/j.brachy.2020.10.008. PMID: 33250304
Glomus tumor in the floor of the mouth: a case report and review of the literature.
Zou H, Song L, Jia M, Wang L, Sun Y
World J Surg Oncol 2018 Oct 10;16(1):201. doi: 10.1186/s12957-018-1503-6. PMID: 30305096Free PMC Article
Intraoral rhabdomyomas.
Corio RL, Lewis DM
Oral Surg Oral Med Oral Pathol 1979 Dec;48(6):525-31. doi: 10.1016/0030-4220(79)90299-8. PMID: 292957

Clinical prediction guides

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
Oral Adult Rhabdomyoma.
da Silva Leonel ACL, Dos Santos ST, de Amorim Carvalho EJ, de Castro JFL, de Almeida OP, da Cruz Perez DE
Head Neck Pathol 2021 Dec;15(4):1253-1260. Epub 2021 Aug 10 doi: 10.1007/s12105-021-01371-z. PMID: 34378165Free PMC Article
Results of postoperative interstitial brachytherapy of resectable floor of mouth tumors.
Ferenczi Ö, Major T, Akiyama H, Fröhlich G, Oberna F, Révész M, Poósz M, Polgár C, Takácsi-Nagy Z
Brachytherapy 2021 Mar-Apr;20(2):376-382. Epub 2020 Nov 26 doi: 10.1016/j.brachy.2020.10.008. PMID: 33250304
Axillary lymph node metastasis in second oropharyngeal cancer.
Alessandro S, Magremanne M, Marbaix E, Reychler H, Mahy P
J Stomatol Oral Maxillofac Surg 2019 Apr;120(2):160-163. Epub 2018 Nov 1 doi: 10.1016/j.jormas.2018.10.010. PMID: 30391374
Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival.
Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY
Am J Surg Pathol 2005 Feb;29(2):167-78. doi: 10.1097/01.pas.0000149687.90710.21. PMID: 15644773

Recent systematic reviews

Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis.
Paglioni MP, Khurram SA, Ruiz BII, Lauby-Secretan B, Normando AG, Ribeiro ACP, Brandão TB, Palmier NR, Lopes MA, da Silva Guerra EN, Meleti M, Migliorati CA, Carvalho AL, de Matos LL, Kowalski LP, Santos-Silva AR
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Nov;134(5):573-587. Epub 2022 Jul 21 doi: 10.1016/j.oooo.2022.07.006. PMID: 36153299
Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Cribriform adenocarcinoma of the tongue and minor salivary glands: a systematic review of an uncommon clinicopathological entity.
De Luca P, Tassone D, de Campora L, Simone M, Marra P, Colacurcio V, Scarpa A, Costarelli L, Camaioni A
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2719-2725. Epub 2021 Oct 23 doi: 10.1007/s00405-021-07140-6. PMID: 34687340
Diagnosis and management of congenital floor of mouth masses: A systematic review.
Lucas JP, Allen M, Siegel B, Gonik N
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110541. Epub 2020 Dec 1 doi: 10.1016/j.ijporl.2020.110541. PMID: 33296834
Systematic review of the platysma myocutaneous flap for head and neck reconstruction.
Szudek J, Taylor SM
Arch Otolaryngol Head Neck Surg 2007 Jul;133(7):655-61. doi: 10.1001/archotol.133.7.655. PMID: 17638777

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