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Floor of Mouth Basaloid Squamous Cell Carcinoma

MedGen UID:
1382431
•Concept ID:
C2204527
•
Neoplastic Process
Synonym: Floor of Mouth BSCC

Definition

An aggressive variant of squamous cell carcinoma that arises from the floor of the mouth. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFloor of Mouth Basaloid Squamous Cell Carcinoma

Recent clinical studies

Etiology

Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature.
Schuch LF, Nóbrega KHS, Gomes APN, Vasconcelos ACU
Oral Maxillofac Surg 2020 Mar;24(1):103-108. Epub 2020 Jan 8 doi: 10.1007/s10006-020-00828-9. PMID: 31912260
Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: an update with special reference to HPV-related carcinomas.
El-Mofty SK
Med Oral Patol Oral Cir Bucal 2014 Jul 1;19(4):e377-85. doi: 10.4317/medoral.20184. PMID: 24880454Free PMC Article
A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology.
Jayasooriya PR, Tilakaratne WM, Mendis BR, Lombardi T
Ann Diagn Pathol 2013 Dec;17(6):547-51. Epub 2013 Oct 21 doi: 10.1016/j.anndiagpath.2013.09.001. PMID: 24157420
Basaloid squamous cell carcinoma of the head and neck.
Paulino AF, Singh B, Shah JP, Huvos AG
Laryngoscope 2000 Sep;110(9):1479-82. doi: 10.1097/00005537-200009000-00013. PMID: 10983946
Basaloid squamous cell carcinoma of floor of mouth.
Coppola D, Catalano E, Tang CK, Elfenbein IB, Harwick R, Mohr R
Cancer 1993 Oct 15;72(8):2299-305. doi: 10.1002/1097-0142(19931015)72:8<2299::aid-cncr2820720803>3.0.co;2-2. PMID: 7691390

Diagnosis

Large cell neuroendocrine carcinoma of the floor of mouth and retromolar trigone in association with basaloid squamous cell carcinoma.
Archibald H, Keel S, Becker E
Int J Oral Maxillofac Surg 2022 Dec;51(12):1520-1524. Epub 2022 May 4 doi: 10.1016/j.ijom.2022.01.020. PMID: 35523694
Revisiting a rare disease: Oral cavity basaloid squamous cell carcinoma at a high-volume tertiary center.
Hicks MD, Lin D, Buczek EP
Am J Otolaryngol 2020 Nov-Dec;41(6):102645. Epub 2020 Jul 7 doi: 10.1016/j.amjoto.2020.102645. PMID: 32682190
Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature.
Schuch LF, Nóbrega KHS, Gomes APN, Vasconcelos ACU
Oral Maxillofac Surg 2020 Mar;24(1):103-108. Epub 2020 Jan 8 doi: 10.1007/s10006-020-00828-9. PMID: 31912260
Basaloid squamous cell carcinoma report of a case and review of literature.
Sundharam BS, Krishnan PA
Indian J Dent Res 2003 Jul-Sep;14(3):184-6. PMID: 15164662
Basaloid squamous cell carcinoma of floor of mouth.
Coppola D, Catalano E, Tang CK, Elfenbein IB, Harwick R, Mohr R
Cancer 1993 Oct 15;72(8):2299-305. doi: 10.1002/1097-0142(19931015)72:8<2299::aid-cncr2820720803>3.0.co;2-2. PMID: 7691390

Prognosis

Basaloid squamous cell carcinoma in the maxillary gingiva.
Protyusha GB, Sivapathasundharam B
J Cancer Res Ther 2021 Jul-Sep;17(4):1108-1111. doi: 10.4103/jcrt.JCRT_893_19. PMID: 34528572
Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: an update with special reference to HPV-related carcinomas.
El-Mofty SK
Med Oral Patol Oral Cir Bucal 2014 Jul 1;19(4):e377-85. doi: 10.4317/medoral.20184. PMID: 24880454Free PMC Article
A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology.
Jayasooriya PR, Tilakaratne WM, Mendis BR, Lombardi T
Ann Diagn Pathol 2013 Dec;17(6):547-51. Epub 2013 Oct 21 doi: 10.1016/j.anndiagpath.2013.09.001. PMID: 24157420
Basaloid squamous cell carcinoma of the head and neck.
Paulino AF, Singh B, Shah JP, Huvos AG
Laryngoscope 2000 Sep;110(9):1479-82. doi: 10.1097/00005537-200009000-00013. PMID: 10983946
Basaloid squamous cell carcinoma of floor of mouth.
Coppola D, Catalano E, Tang CK, Elfenbein IB, Harwick R, Mohr R
Cancer 1993 Oct 15;72(8):2299-305. doi: 10.1002/1097-0142(19931015)72:8<2299::aid-cncr2820720803>3.0.co;2-2. PMID: 7691390

Clinical prediction guides

A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology.
Jayasooriya PR, Tilakaratne WM, Mendis BR, Lombardi T
Ann Diagn Pathol 2013 Dec;17(6):547-51. Epub 2013 Oct 21 doi: 10.1016/j.anndiagpath.2013.09.001. PMID: 24157420
Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas.
Lingen MW, Xiao W, Schmitt A, Jiang B, Pickard R, Kreinbrink P, Perez-Ordonez B, Jordan RC, Gillison ML
Oral Oncol 2013 Jan;49(1):1-8. Epub 2012 Jul 28 doi: 10.1016/j.oraloncology.2012.07.002. PMID: 22841678
Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report.
Joshi D, Shivkumar VB, Sharma SM, Gangane N
Acta Cytol 2009 Jan-Feb;53(1):89-92. doi: 10.1159/000325090. PMID: 19248560

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