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Pineal gland cancer

MedGen UID:
102284
•Concept ID:
C0153655
•
Neoplastic Process
Synonyms: cancer of pineal body; Cancer of pineal gland; malignant neoplasm of pineal body; Malignant Neoplasm of Pineal Gland; malignant neoplasm of pineal gland; Malignant Neoplasm of the Pineal Gland; malignant neoplasm of the pineal gland; Malignant Pineal Area Neoplasm; malignant pineal area neoplasm; Malignant Pineal Area Tumor; malignant pineal area tumor; malignant pineal area tumour; malignant pineal body neoplasm; Malignant Pineal Gland Neoplasm; malignant pineal gland neoplasm; Malignant Pineal Gland Tumor; malignant pineal gland tumor; malignant pineal gland tumour; Malignant Pineal Region Neoplasm; malignant pineal region neoplasm; Malignant Pineal Region Tumor; malignant pineal region tumor; malignant pineal region tumour; Malignant tumor of pineal gland; Malignant Tumor of Pineal Gland; malignant tumor of pineal gland; Malignant Tumor of the Pineal Gland; malignant tumor of the pineal gland; malignant tumour of pineal gland; malignant tumour of the pineal gland; pineal body cancer; Pineal cancer; pineal gland cancer; pinealoma
SNOMED CT: Pineal cancer (363483004); Cancer of pineal gland (363483004); Malignant tumor of pineal gland (363483004)
 
Monarch Initiative: MONDO:0003249

Definition

A malignant neoplasm that affects the pineal region. [from NCI]

Professional guidelines

PubMed

Potential role of melatonin in prevention and treatment of lung cancer.
Ngai ZN, Chok KC, Ng KY, Koh RY, Chye SM
Horm Mol Biol Clin Investig 2022 Dec 1;43(4):485-503. Epub 2022 Jun 22 doi: 10.1515/hmbci-2022-0018. PMID: 35728260
Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.
Talib WH, Alsayed AR, Abuawad A, Daoud S, Mahmod AI
Molecules 2021 Apr 25;26(9) doi: 10.3390/molecules26092506. PMID: 33923028Free PMC Article
Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment.
Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, Najafi M, Sahebkar A
J Cell Physiol 2019 May;234(5):5613-5627. Epub 2018 Sep 21 doi: 10.1002/jcp.27391. PMID: 30238978

Recent clinical studies

Etiology

Pineal/germ cell tumors and pineal parenchymal tumors.
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
In and around the pineal gland: a neuroimaging review.
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment.
Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, Najafi M, Sahebkar A
J Cell Physiol 2019 May;234(5):5613-5627. Epub 2018 Sep 21 doi: 10.1002/jcp.27391. PMID: 30238978
Pineal tumors.
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647

Diagnosis

In and around the pineal gland: a neuroimaging review.
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Neuroimaging of paediatric pineal, sellar and suprasellar tumours: a guide to differential diagnosis.
Lim EA, Alves CAPF, Picariello S, Aquilina K, Bisdas S, Loebel U, Mankad K, D'Arco F
Childs Nerv Syst 2022 Jan;38(1):33-50. Epub 2021 Sep 16 doi: 10.1007/s00381-021-05359-6. PMID: 34529090
Imagery of pineal tumors.
Deiana G, Mottolese C, Hermier M, Louis-Tisserand G, Berthezene Y
Neurochirurgie 2015 Apr-Jun;61(2-3):113-22. Epub 2015 Feb 9 doi: 10.1016/j.neuchi.2014.10.111. PMID: 25676911
Pineal tumors.
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647
Pineal tumors.
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580

Therapy

Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders.
Ahmad SB, Ali A, Bilal M, Rashid SM, Wani AB, Bhat RR, Rehman MU
Cell Mol Neurobiol 2023 Aug;43(6):2437-2458. Epub 2023 Feb 8 doi: 10.1007/s10571-023-01324-w. PMID: 36752886Free PMC Article
Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.
Ma ZQ, Feng YT, Guo K, Liu D, Shao CJ, Pan MH, Zhang YM, Zhang YX, Lu D, Huang D, Zhang F, Wang JL, Yang B, Han J, Yan XL, Hu Y
Mil Med Res 2022 Sep 27;9(1):54. doi: 10.1186/s40779-022-00412-0. PMID: 36163081Free PMC Article
Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.
Talib WH, Alsayed AR, Abuawad A, Daoud S, Mahmod AI
Molecules 2021 Apr 25;26(9) doi: 10.3390/molecules26092506. PMID: 33923028Free PMC Article
Melatonin and its ubiquitous anticancer effects.
Bhattacharya S, Patel KK, Dehari D, Agrawal AK, Singh S
Mol Cell Biochem 2019 Dec;462(1-2):133-155. Epub 2019 Aug 26 doi: 10.1007/s11010-019-03617-5. PMID: 31451998
Fluoride Exposure in Early Life as the Possible Root Cause of Disease In Later Life.
Nakamoto T, Rawls HR
J Clin Pediatr Dent 2018;42(5):325-330. Epub 2018 May 15 doi: 10.17796/1053-4625-42.5.1. PMID: 29763350

Prognosis

Histopathology and molecular pathology of pediatric pineal parenchymal tumors.
Vasiljevic A
Childs Nerv Syst 2023 Sep;39(9):2273-2284. Epub 2022 Aug 16 doi: 10.1007/s00381-022-05637-x. PMID: 35972537
Pineal Apoplexy: A Case Series and Review of the Literature.
Majovsky M, Netuka D, Lipina R, Mraček J, Beneš V
J Neurol Surg A Cent Eur Neurosurg 2022 Jan;83(1):31-38. Epub 2021 Jun 2 doi: 10.1055/s-0041-1723813. PMID: 34077982
Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Pineal tumors.
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580

Clinical prediction guides

Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.
Ma ZQ, Feng YT, Guo K, Liu D, Shao CJ, Pan MH, Zhang YM, Zhang YX, Lu D, Huang D, Zhang F, Wang JL, Yang B, Han J, Yan XL, Hu Y
Mil Med Res 2022 Sep 27;9(1):54. doi: 10.1186/s40779-022-00412-0. PMID: 36163081Free PMC Article
Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders.
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yuen HP, Phillips LJ, Suzuki M, McGorry PD, Velakoulis D, Pantelis C
Schizophr Res 2022 Jun;244:1-7. Epub 2022 Apr 26 doi: 10.1016/j.schres.2022.04.005. PMID: 35487129
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Pineal Apoplexy: A Case Series and Review of the Literature.
Majovsky M, Netuka D, Lipina R, Mraček J, Beneš V
J Neurol Surg A Cent Eur Neurosurg 2022 Jan;83(1):31-38. Epub 2021 Jun 2 doi: 10.1055/s-0041-1723813. PMID: 34077982
Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF.
Cheng J, Yang HL, Gu CJ, Liu YK, Shao J, Zhu R, He YY, Zhu XY, Li MQ
Int J Mol Med 2019 Feb;43(2):945-955. Epub 2018 Dec 10 doi: 10.3892/ijmm.2018.4021. PMID: 30569127Free PMC Article

Recent systematic reviews

Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Surgical treatment of symptomatic pineal cysts without hydrocephalus-meta-analysis of the published literature.
Masina R, Ansaripour A, Beneš V, Berhouma M, Choque-Velasquez J, Eide PK, Fedorko S, Fleck S, Hernesniemi J, Koziarski A, Májovský M, Podgorski A, Schroeder H, Teo C, Unterberg AW, Yeung JT, Kolias A, Santarius T
Acta Neurochir (Wien) 2022 Jan;164(1):61-77. Epub 2021 Dec 2 doi: 10.1007/s00701-021-05054-0. PMID: 34854993Free PMC Article
Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
Systematic review of pineal cysts surgery in pediatric patients.
Choque-Velasquez J, Colasanti R, Baluszek S, Resendiz-Nieves J, Muhammad S, Ludtka C, Hernesniemi J
Childs Nerv Syst 2020 Dec;36(12):2927-2938. Epub 2020 Jul 20 doi: 10.1007/s00381-020-04792-3. PMID: 32691194Free PMC Article

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