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Malignant pineal area germ cell neoplasm

MedGen UID:
233159
•Concept ID:
C1334612
•
Neoplastic Process
Synonyms: Malignant Germ Cell Neoplasm of Pineal Gland; malignant germ cell neoplasm of pineal gland; Malignant Germ Cell Neoplasm of Pineal Parenchyma; malignant germ cell neoplasm of pineal parenchyma; Malignant Germ Cell Neoplasm of the Pineal Gland; malignant germ cell neoplasm of the pineal gland; Malignant Germ Cell Neoplasm of the Pineal Parenchyma; malignant germ cell neoplasm of the pineal parenchyma; Malignant Germ Cell Tumor of Pineal Gland; malignant germ cell tumor of pineal gland; Malignant Germ Cell Tumor of Pineal Parenchyma; malignant germ cell tumor of pineal parenchyma; Malignant Germ Cell Tumor of the Pineal Gland; malignant germ cell tumor of the pineal gland; Malignant Germ Cell Tumor of the Pineal Parenchyma; malignant germ cell tumor of the pineal parenchyma; malignant germ cell tumour of pineal gland; malignant germ cell tumour of pineal parenchyma; malignant germ cell tumour of the pineal gland; malignant germ cell tumour of the pineal parenchyma; Malignant Pineal Area Germ Cell Neoplasm; malignant pineal area germ cell neoplasm; Malignant Pineal Area Germ Cell Tumor; malignant pineal area germ cell tumor; malignant pineal area germ cell tumour; Malignant Pineal Gland Germ Cell Neoplasm; malignant pineal gland germ cell neoplasm; Malignant Pineal Gland Germ Cell Tumor; malignant pineal gland germ cell tumor; malignant pineal gland germ cell tumour; Malignant Pineal Parenchymal Germ Cell Neoplasm; malignant pineal parenchymal germ cell neoplasm; Malignant Pineal Parenchymal Germ Cell Tumor; malignant pineal parenchymal germ cell tumor; malignant pineal parenchymal germ cell tumour; Malignant Pineal Region Germ Cell Neoplasm; malignant pineal region germ cell neoplasm; Malignant Pineal Region Germ Cell Tumor; malignant pineal region germ cell tumor; malignant pineal region germ cell tumour; pineal cell tumor; pineal cell tumour; Pineal Germ Cell Neoplasm, Malignant; pineal germ cell neoplasm, malignant; pineal germ cell tumor; pineal germ cell tumour; pineal region germ cell tumor; pineal region germ cell tumour; pineal region germinoma
 
Monarch Initiative: MONDO:0002073

Definition

A malignant germ cell tumor that arises in the pineal region. Representative examples include germinoma, immature teratoma, choriocarcinoma, embryonal carcinoma and yolk sac tumor. [from NCI]

Professional guidelines

PubMed

Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort.
Stephens S, Kuchel A, Cheuk R, Alexander H, Robertson T, Rajah T, Tran Q, Inglis PL
J Clin Neurosci 2021 Aug;90:1-7. Epub 2021 May 21 doi: 10.1016/j.jocn.2021.05.006. PMID: 34275531
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns.
Bhimani AD, Barrington NM, Aguilar TM, Arnone GD, Mehta AI
Pituitary 2020 Aug;23(4):381-388. doi: 10.1007/s11102-020-01042-2. PMID: 32388804
Management of intracranial germ cell tumors at the King Chulalongkorn Memorial Hospital.
Raiyawa T, Khorprasert C, Lertbutsayanukul C, Seksarn P, Sosothikul D, Amornfa J, Shotelersuk K
J Med Assoc Thai 2012 Oct;95(10):1327-34. PMID: 23193749

Recent clinical studies

Etiology

Brain and Spinal Tumors Originating from the Germ Line Cells.
Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Accuracy of apparent diffusion coefficient values for distinguishing between pineal germ cell tumour and pineoblastoma.
Panyaping T, Tritanon O, Wisetsathon P, Chansakul T, Pongpitcha P
Clin Radiol 2023 Jul;78(7):e494-e501. Epub 2023 Mar 25 doi: 10.1016/j.crad.2023.03.008. PMID: 37037704
In and around the pineal gland: a neuroimaging review.
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Novel Diagnostic Methods and Posttreatment Clinical Phenotypes Among Intracranial Germ Cell Tumors.
Takami H, Perry A, Graffeo CS, Giannini C, Daniels DJ
Neurosurgery 2020 Sep 1;87(3):563-572. doi: 10.1093/neuros/nyaa108. PMID: 32348488
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Diagnosis

Brain and Spinal Tumors Originating from the Germ Line Cells.
Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
In and around the pineal gland: a neuroimaging review.
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Novel Diagnostic Methods and Posttreatment Clinical Phenotypes Among Intracranial Germ Cell Tumors.
Takami H, Perry A, Graffeo CS, Giannini C, Daniels DJ
Neurosurgery 2020 Sep 1;87(3):563-572. doi: 10.1093/neuros/nyaa108. PMID: 32348488
Pineal germ cell tumors: review.
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Therapy

Feasibility of treating pediatric intracranial germ cell tumors in a middle-income country: The Jordanian experience.
Amayiri N, Sarhan N, Yousef Y, Ibrahimi AK, Abu-Shanab S, Al-Zebin Z, Al-Hussaini M, Musharbash A, Tawalbeh A, Bouffet E, Bartels U
Pediatr Blood Cancer 2022 Dec;69(12):e30011. Epub 2022 Sep 21 doi: 10.1002/pbc.30011. PMID: 36131594
Primary intracranial germ cell tumors in children 36-year experience of a single center.
Kurucu N, Akyüz C, Varan A, Zorlu F, Aydin B, Söylemezoglu F, Yalcin B, Kutluk T, Büyükpamukcus M
J Cancer Res Ther 2020 Oct-Dec;16(6):1459-1465. doi: 10.4103/jcrt.JCRT_314_18. PMID: 33342813
Canadian patterns of practice for intracranial germ cell tumors in adolescents and young adults.
Lo AC, Laperriere N, Hodgson D, Bouffet E, Nicholson J, McKenzie M, Hukin J, Cheng S, Goddard KJ
J Neurooncol 2019 Jun;143(2):289-296. Epub 2019 Apr 1 doi: 10.1007/s11060-019-03159-2. PMID: 30937607
Latency of intracranial germ cell tumors and diagnosis delay.
Phi JH, Kim SK, Lee YA, Shin CH, Cheon JE, Kim IO, Yang SW, Wang KC
Childs Nerv Syst 2013 Oct;29(10):1871-81. Epub 2013 Jun 29 doi: 10.1007/s00381-013-2164-y. PMID: 23811803
Intracranial germ cell tumors: a single-institution experience.
Khafaga Y, El Weshi A, Nazmy M, Hassounah M, Alshail E, Moussa E, Allam A, Alkofide A, Jamshed A, ELhusseiny G, Ezzat I, Jenkin D
Ann Saudi Med 2012 Jul-Aug;32(4):359-65. doi: 10.5144/0256-4947.2012.359. PMID: 22705605Free PMC Article

Prognosis

Brain and Spinal Tumors Originating from the Germ Line Cells.
Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Canadian patterns of practice for intracranial germ cell tumors in adolescents and young adults.
Lo AC, Laperriere N, Hodgson D, Bouffet E, Nicholson J, McKenzie M, Hukin J, Cheng S, Goddard KJ
J Neurooncol 2019 Jun;143(2):289-296. Epub 2019 Apr 1 doi: 10.1007/s11060-019-03159-2. PMID: 30937607
Latency of intracranial germ cell tumors and diagnosis delay.
Phi JH, Kim SK, Lee YA, Shin CH, Cheon JE, Kim IO, Yang SW, Wang KC
Childs Nerv Syst 2013 Oct;29(10):1871-81. Epub 2013 Jun 29 doi: 10.1007/s00381-013-2164-y. PMID: 23811803
Pineal germ cell tumors: review.
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Clinical prediction guides

Primary intracranial germ cell tumors in children 36-year experience of a single center.
Kurucu N, Akyüz C, Varan A, Zorlu F, Aydin B, Söylemezoglu F, Yalcin B, Kutluk T, Büyükpamukcus M
J Cancer Res Ther 2020 Oct-Dec;16(6):1459-1465. doi: 10.4103/jcrt.JCRT_314_18. PMID: 33342813
Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies.
Bost C, Chanson E, Picard G, Meyronet D, Mayeur ME, Ducray F, Rogemond V, Psimaras D, Antoine JC, Delattre JY, Desestret V, Honnorat J
J Neurol 2018 Oct;265(10):2190-2200. Epub 2018 Jul 12 doi: 10.1007/s00415-018-8970-0. PMID: 30003358
Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India.
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934
Pineal germ cell tumors: review.
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168
Suprasellar germinoma.
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Recent systematic reviews

Predictive factors of overall survival in primary intracranial pure choriocarcinoma.
Jiang T, Raynald, Yang H, Zhang W, Li C
J Clin Neurosci 2019 Mar;61:93-101. Epub 2018 Nov 12 doi: 10.1016/j.jocn.2018.10.136. PMID: 30442453

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