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Malignant pineal area germ cell neoplasm

MedGen UID:
233159
Concept ID:
C1334612
Neoplastic Process
Synonyms: Malignant Germ Cell Neoplasm of Pineal Gland; malignant germ cell neoplasm of pineal gland; Malignant Germ Cell Neoplasm of Pineal Parenchyma; malignant germ cell neoplasm of pineal parenchyma; Malignant Germ Cell Neoplasm of the Pineal Gland; malignant germ cell neoplasm of the pineal gland; Malignant Germ Cell Neoplasm of the Pineal Parenchyma; malignant germ cell neoplasm of the pineal parenchyma; Malignant Germ Cell Tumor of Pineal Gland; malignant germ cell tumor of pineal gland; Malignant Germ Cell Tumor of Pineal Parenchyma; malignant germ cell tumor of pineal parenchyma; Malignant Germ Cell Tumor of the Pineal Gland; malignant germ cell tumor of the pineal gland; Malignant Germ Cell Tumor of the Pineal Parenchyma; malignant germ cell tumor of the pineal parenchyma; malignant germ cell tumour of pineal gland; malignant germ cell tumour of pineal parenchyma; malignant germ cell tumour of the pineal gland; malignant germ cell tumour of the pineal parenchyma; Malignant Pineal Area Germ Cell Neoplasm; malignant pineal area germ cell neoplasm; Malignant Pineal Area Germ Cell Tumor; malignant pineal area germ cell tumor; malignant pineal area germ cell tumour; Malignant Pineal Gland Germ Cell Neoplasm; malignant pineal gland germ cell neoplasm; Malignant Pineal Gland Germ Cell Tumor; malignant pineal gland germ cell tumor; malignant pineal gland germ cell tumour; Malignant Pineal Parenchymal Germ Cell Neoplasm; malignant pineal parenchymal germ cell neoplasm; Malignant Pineal Parenchymal Germ Cell Tumor; malignant pineal parenchymal germ cell tumor; malignant pineal parenchymal germ cell tumour; Malignant Pineal Region Germ Cell Neoplasm; malignant pineal region germ cell neoplasm; Malignant Pineal Region Germ Cell Tumor; malignant pineal region germ cell tumor; malignant pineal region germ cell tumour; pineal cell tumor; pineal cell tumour; Pineal Germ Cell Neoplasm, Malignant; pineal germ cell neoplasm, malignant; pineal germ cell tumor; pineal germ cell tumour; pineal region germ cell tumor; pineal region germ cell tumour; pineal region germinoma
 
Monarch Initiative: MONDO:0002073

Definition

A malignant germ cell tumor that arises in the pineal region. Representative examples include germinoma, immature teratoma, choriocarcinoma, embryonal carcinoma and yolk sac tumor. [from NCI]

Professional guidelines

PubMed

Stephens S, Kuchel A, Cheuk R, Alexander H, Robertson T, Rajah T, Tran Q, Inglis PL
J Clin Neurosci 2021 Aug;90:1-7. Epub 2021 May 21 doi: 10.1016/j.jocn.2021.05.006. PMID: 34275531
Bhimani AD, Barrington NM, Aguilar TM, Arnone GD, Mehta AI
Pituitary 2020 Aug;23(4):381-388. doi: 10.1007/s11102-020-01042-2. PMID: 32388804
Mynarek M, Pizer B, Dufour C, van Vuurden D, Garami M, Massimino M, Fangusaro J, Davidson T, Gil-da-Costa MJ, Sterba J, Benesch M, Gerber N, Juhnke BO, Kwiecien R, Pietsch T, Kool M, Clifford S, Ellison DW, Giangaspero F, Wesseling P, Gilles F, Gottardo N, Finlay JL, Rutkowski S, von Hoff K
Neuro Oncol 2017 Apr 1;19(4):576-585. doi: 10.1093/neuonc/now234. PMID: 28011926Free PMC Article

Recent clinical studies

Etiology

Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Enam SA, Shah MM, Bajwa MH, Khalid MU, Bakhshi SK, Baig E, Altaf IA, Laghari AA, Anis SB, Akhunzada NZ, Raghib MF, Gilani JA, Jawed N; Pakistan Brain Tumour Consortium, Siddiqi S; Pakistan Brain Tumour Consortium Group Names
J Pak Med Assoc 2022 Nov;72(Suppl 4)(11):S4-S11. doi: 10.47391/JPMA.11-S4-AKUB01. PMID: 36591621
Quick-Weller J, Lescher S, Baumgarten P, Dinc N, Bruder M, Weise L, Seifert V, Marquardt G
World Neurosurg 2016 Dec;96:124-128. Epub 2016 Jun 7 doi: 10.1016/j.wneu.2016.04.130. PMID: 27287513
Nevins EJ, Das K, Bhojak M, Pinto RS, Hoque MN, Jenkinson MD, Chavredakis E
World Neurosurg 2016 Jun;90:96-102. Epub 2016 Mar 2 doi: 10.1016/j.wneu.2016.02.092. PMID: 26944882
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Diagnosis

Tahta A, Akalan N
Adv Tech Stand Neurosurg 2023;46:53-64. doi: 10.1007/978-3-031-28202-7_3. PMID: 37318569
Kim YH, Phi JH, Kim SK, Wang KC
Childs Nerv Syst 2023 Sep;39(9):2367-2375. Epub 2022 Sep 16 doi: 10.1007/s00381-022-05654-w. PMID: 36112201
Enam SA, Shah MM, Bajwa MH, Khalid MU, Bakhshi SK, Baig E, Altaf IA, Laghari AA, Anis SB, Akhunzada NZ, Raghib MF, Gilani JA, Jawed N; Pakistan Brain Tumour Consortium, Siddiqi S; Pakistan Brain Tumour Consortium Group Names
J Pak Med Assoc 2022 Nov;72(Suppl 4)(11):S4-S11. doi: 10.47391/JPMA.11-S4-AKUB01. PMID: 36591621
Yang M, Chen X, Wang N, Zhu K, Hu YZ, Zhao Y, Shu Y, Zhao ML, Gu WZ, Tang HF
Int J Clin Exp Pathol 2014;7(5):2411-20. Epub 2014 Apr 15 PMID: 24966951Free PMC Article
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Therapy

Fan Y, Huo X, Li X, Wang L, Wu Z
Radiother Oncol 2022 Feb;167:277-284. Epub 2022 Jan 13 doi: 10.1016/j.radonc.2022.01.005. PMID: 35033600
Liang J, Gao C, Zhu Y, Ling C, Wang Q, Huang Y, Qin J, Wang J, Lu W, Wang J
ACS Appl Mater Interfaces 2018 Sep 12;10(36):30201-30213. Epub 2018 Sep 4 doi: 10.1021/acsami.8b11782. PMID: 30113810
Lim FP, Soh SY, Iyer JV, Tan AM, Swati H, Quah BL
J Pediatr Ophthalmol Strabismus 2013 Mar-Apr;50(2):106-12. Epub 2012 Dec 18 doi: 10.3928/01913913-20121211-01. PMID: 23244241
Hayashi N, Murai H, Ishihara S, Kitamura T, Miki T, Miwa T, Miyajima M, Nishiyama K, Ohira T, Ono S, Suzuki T, Takano S, Date I, Saeki N, Endo S
J Neurosurg 2011 Dec;115(6):1147-57. Epub 2011 Aug 12 doi: 10.3171/2011.7.JNS101976. PMID: 21838511
Brada M, Laing R
Recent Results Cancer Res 1994;135:91-104. doi: 10.1007/978-3-642-85039-4_10. PMID: 7519356

Prognosis

Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Ye N, Yang Q, Liu P, Chen Z, Li X
Comput Biol Med 2023 Jan;152:106366. Epub 2022 Nov 26 doi: 10.1016/j.compbiomed.2022.106366. PMID: 36470145
Hu X, Ren YM, Yang X, Liu XD, Huang BW, Chen TY, Jv Y, Lan ZG, Liu WK, Liu XS, Hui XH, Liu JP, Zhang YK
World Neurosurg 2023 Apr;172:e1-e11. Epub 2022 Sep 24 doi: 10.1016/j.wneu.2022.09.091. PMID: 36167302
Nevins EJ, Das K, Bhojak M, Pinto RS, Hoque MN, Jenkinson MD, Chavredakis E
World Neurosurg 2016 Jun;90:96-102. Epub 2016 Mar 2 doi: 10.1016/j.wneu.2016.02.092. PMID: 26944882
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Clinical prediction guides

Ye N, Yang Q, Liu P, Chen Z, Li X
Comput Biol Med 2023 Jan;152:106366. Epub 2022 Nov 26 doi: 10.1016/j.compbiomed.2022.106366. PMID: 36470145
Hu X, Ren YM, Yang X, Liu XD, Huang BW, Chen TY, Jv Y, Lan ZG, Liu WK, Liu XS, Hui XH, Liu JP, Zhang YK
World Neurosurg 2023 Apr;172:e1-e11. Epub 2022 Sep 24 doi: 10.1016/j.wneu.2022.09.091. PMID: 36167302
Faure Conter C, Fresneau B, Thebaud E, Bertrand A, Dijoud F, Rome A, Dumesnil C, Castex MP, Ghanem A, Orbach D
J Pediatr Hematol Oncol 2017 Jul;39(5):388-394. doi: 10.1097/MPH.0000000000000823. PMID: 28375941
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Recent systematic reviews

Jiang T, Raynald, Yang H, Zhang W, Li C
J Clin Neurosci 2019 Mar;61:93-101. Epub 2018 Nov 12 doi: 10.1016/j.jocn.2018.10.136. PMID: 30442453

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