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Malignant pineal area germ cell neoplasm

MedGen UID:
233159
Concept ID:
C1334612
Neoplastic Process
Synonyms: Malignant Germ Cell Neoplasm of Pineal Gland; malignant germ cell neoplasm of pineal gland; Malignant Germ Cell Neoplasm of Pineal Parenchyma; malignant germ cell neoplasm of pineal parenchyma; Malignant Germ Cell Neoplasm of the Pineal Gland; malignant germ cell neoplasm of the pineal gland; Malignant Germ Cell Neoplasm of the Pineal Parenchyma; malignant germ cell neoplasm of the pineal parenchyma; Malignant Germ Cell Tumor of Pineal Gland; malignant germ cell tumor of pineal gland; Malignant Germ Cell Tumor of Pineal Parenchyma; malignant germ cell tumor of pineal parenchyma; Malignant Germ Cell Tumor of the Pineal Gland; malignant germ cell tumor of the pineal gland; Malignant Germ Cell Tumor of the Pineal Parenchyma; malignant germ cell tumor of the pineal parenchyma; malignant germ cell tumour of pineal gland; malignant germ cell tumour of pineal parenchyma; malignant germ cell tumour of the pineal gland; malignant germ cell tumour of the pineal parenchyma; Malignant Pineal Area Germ Cell Neoplasm; malignant pineal area germ cell neoplasm; Malignant Pineal Area Germ Cell Tumor; malignant pineal area germ cell tumor; malignant pineal area germ cell tumour; Malignant Pineal Gland Germ Cell Neoplasm; malignant pineal gland germ cell neoplasm; Malignant Pineal Gland Germ Cell Tumor; malignant pineal gland germ cell tumor; malignant pineal gland germ cell tumour; Malignant Pineal Parenchymal Germ Cell Neoplasm; malignant pineal parenchymal germ cell neoplasm; Malignant Pineal Parenchymal Germ Cell Tumor; malignant pineal parenchymal germ cell tumor; malignant pineal parenchymal germ cell tumour; Malignant Pineal Region Germ Cell Neoplasm; malignant pineal region germ cell neoplasm; Malignant Pineal Region Germ Cell Tumor; malignant pineal region germ cell tumor; malignant pineal region germ cell tumour; pineal cell tumor; pineal cell tumour; Pineal Germ Cell Neoplasm, Malignant; pineal germ cell neoplasm, malignant; pineal germ cell tumor; pineal germ cell tumour; pineal region germ cell tumor; pineal region germ cell tumour; pineal region germinoma
 
Monarch Initiative: MONDO:0002073

Definition

A malignant germ cell tumor that arises in the pineal region. Representative examples include germinoma, immature teratoma, choriocarcinoma, embryonal carcinoma and yolk sac tumor. [from NCI]

Professional guidelines

PubMed

Stephens S, Kuchel A, Cheuk R, Alexander H, Robertson T, Rajah T, Tran Q, Inglis PL
J Clin Neurosci 2021 Aug;90:1-7. Epub 2021 May 21 doi: 10.1016/j.jocn.2021.05.006. PMID: 34275531
Bhimani AD, Barrington NM, Aguilar TM, Arnone GD, Mehta AI
Pituitary 2020 Aug;23(4):381-388. doi: 10.1007/s11102-020-01042-2. PMID: 32388804
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934

Recent clinical studies

Etiology

Enam SA, Shah MM, Bajwa MH, Khalid MU, Bakhshi SK, Baig E, Altaf IA, Laghari AA, Anis SB, Akhunzada NZ, Raghib MF, Gilani JA, Jawed N; Pakistan Brain Tumour Consortium, Siddiqi S; Pakistan Brain Tumour Consortium Group Names
J Pak Med Assoc 2022 Nov;72(Suppl 4)(11):S4-S11. doi: 10.47391/JPMA.11-S4-AKUB01. PMID: 36591621
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Stephens S, Kuchel A, Cheuk R, Alexander H, Robertson T, Rajah T, Tran Q, Inglis PL
J Clin Neurosci 2021 Aug;90:1-7. Epub 2021 May 21 doi: 10.1016/j.jocn.2021.05.006. PMID: 34275531
Takami H, Perry A, Graffeo CS, Giannini C, Daniels DJ
Neurosurgery 2020 Sep 1;87(3):563-572. doi: 10.1093/neuros/nyaa108. PMID: 32348488
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Diagnosis

Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Takami H, Perry A, Graffeo CS, Giannini C, Daniels DJ
Neurosurgery 2020 Sep 1;87(3):563-572. doi: 10.1093/neuros/nyaa108. PMID: 32348488
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Therapy

Amayiri N, Sarhan N, Yousef Y, Ibrahimi AK, Abu-Shanab S, Al-Zebin Z, Al-Hussaini M, Musharbash A, Tawalbeh A, Bouffet E, Bartels U
Pediatr Blood Cancer 2022 Dec;69(12):e30011. Epub 2022 Sep 21 doi: 10.1002/pbc.30011. PMID: 36131594
Kurucu N, Akyüz C, Varan A, Zorlu F, Aydin B, Söylemezoglu F, Yalcin B, Kutluk T, Büyükpamukcus M
J Cancer Res Ther 2020 Oct-Dec;16(6):1459-1465. doi: 10.4103/jcrt.JCRT_314_18. PMID: 33342813
Lo AC, Laperriere N, Hodgson D, Bouffet E, Nicholson J, McKenzie M, Hukin J, Cheng S, Goddard KJ
J Neurooncol 2019 Jun;143(2):289-296. Epub 2019 Apr 1 doi: 10.1007/s11060-019-03159-2. PMID: 30937607
Phi JH, Kim SK, Lee YA, Shin CH, Cheon JE, Kim IO, Yang SW, Wang KC
Childs Nerv Syst 2013 Oct;29(10):1871-81. Epub 2013 Jun 29 doi: 10.1007/s00381-013-2164-y. PMID: 23811803
Khafaga Y, El Weshi A, Nazmy M, Hassounah M, Alshail E, Moussa E, Allam A, Alkofide A, Jamshed A, ELhusseiny G, Ezzat I, Jenkin D
Ann Saudi Med 2012 Jul-Aug;32(4):359-65. doi: 10.5144/0256-4947.2012.359. PMID: 22705605Free PMC Article

Prognosis

Lo AC, Laperriere N, Hodgson D, Bouffet E, Nicholson J, McKenzie M, Hukin J, Cheng S, Goddard KJ
J Neurooncol 2019 Jun;143(2):289-296. Epub 2019 Apr 1 doi: 10.1007/s11060-019-03159-2. PMID: 30937607
Phi JH, Kim SK, Lee YA, Shin CH, Cheon JE, Kim IO, Yang SW, Wang KC
Childs Nerv Syst 2013 Oct;29(10):1871-81. Epub 2013 Jun 29 doi: 10.1007/s00381-013-2164-y. PMID: 23811803
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982
Dearnaley DP, A'Hern RP, Whittaker S, Bloom HJ
Int J Radiat Oncol Biol Phys 1990 Apr;18(4):773-81. doi: 10.1016/0360-3016(90)90396-2. PMID: 2323968

Clinical prediction guides

Kumar N, Madan R, Dracham CB, Khosla D, Das N, Dey T, Elangovan A, Tripathi M, Gupta K, Ahuja CK, Kapoor R
Clin Neurol Neurosurg 2021 Mar;202:106481. Epub 2021 Jan 13 doi: 10.1016/j.clineuro.2021.106481. PMID: 33508649
Kurucu N, Akyüz C, Varan A, Zorlu F, Aydin B, Söylemezoglu F, Yalcin B, Kutluk T, Büyükpamukcus M
J Cancer Res Ther 2020 Oct-Dec;16(6):1459-1465. doi: 10.4103/jcrt.JCRT_314_18. PMID: 33342813
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168
Takeuchi J, Handa H, Nagata I
J Neurosurg 1978 Jul;49(1):41-8. doi: 10.3171/jns.1978.49.1.0041. PMID: 660267

Recent systematic reviews

Jiang T, Raynald, Yang H, Zhang W, Li C
J Clin Neurosci 2019 Mar;61:93-101. Epub 2018 Nov 12 doi: 10.1016/j.jocn.2018.10.136. PMID: 30442453

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