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Neonatal myasthenia gravis

MedGen UID:
102360
Concept ID:
C0158982
Disease or Syndrome
Synonyms: Myasthenia Gravis, Neonatal; Neonatal Myasthenia Gravis
SNOMED CT: Neonatal myasthenia gravis (82178003)
 
Monarch Initiative: MONDO:0006866

Definition

A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal myasthenia gravis

Professional guidelines

PubMed

Hassan A, Yasawy ZM
Sultan Qaboos Univ Med J 2017 Aug;17(3):e259-e267. Epub 2017 Oct 10 doi: 10.18295/squmj.2017.17.03.002. PMID: 29062547Free PMC Article
Brown LW
Rev Infect Dis 1979 Jul-Aug;1(4):625-9. doi: 10.1093/clinids/1.4.625. PMID: 233167

Recent clinical studies

Etiology

Grover KM, Sripathi N
Muscle Nerve 2020 Dec;62(6):664-672. Epub 2020 Sep 28 doi: 10.1002/mus.27064. PMID: 32929722
Waters J
Neurol Clin 2019 Feb;37(1):113-120. doi: 10.1016/j.ncl.2018.09.003. PMID: 30470270
Hamel J, Ciafaloni E
Neurol Clin 2018 May;36(2):355-365. doi: 10.1016/j.ncl.2018.01.005. PMID: 29655454
Vrinten C, van der Zwaag AM, Weinreich SS, Scholten RJ, Verschuuren JJ
Cochrane Database Syst Rev 2014 Dec 17;2014(12):CD010028. doi: 10.1002/14651858.CD010028.pub2. PMID: 25515947Free PMC Article
Papazian O
J Child Neurol 1992 Apr;7(2):135-41. doi: 10.1177/088307389200700202. PMID: 1573230

Diagnosis

Bricoune O, Hamner B, Gieron-Korthals M
Adv Pediatr 2023 Aug;70(1):81-90. Epub 2023 May 10 doi: 10.1016/j.yapd.2023.03.007. PMID: 37422299
Allen NM, O'Rahelly M, Eymard B, Chouchane M, Hahn A, Kearns G, Kim DS, Byun SY, Nguyen CE, Schara-Schmidt U, Kölbel H, Marina AD, Schneider-Gold C, Roefke K, Thieme A, Van den Bergh P, Avalos G, Álvarez-Velasco R, Natera-de Benito D, Cheng MHM, Chan WK, Wan HS, Thomas MA, Borch L, Lauzon J, Kornblum C, Reimann J, Mueller A, Kuntzer T, Norwood F, Ramdas S, Jacobson LW, Jie X, Fernandez-Garcia MA, Wraige E, Lim M, Lin JP, Claeys KG, Aktas S, Oskoui M, Hacohen Y, Masud A, Leite MI, Palace J, De Vivo D, Vincent A, Jungbluth H
Brain 2023 Oct 3;146(10):4233-4246. doi: 10.1093/brain/awad153. PMID: 37186601Free PMC Article
Grover KM, Sripathi N
Muscle Nerve 2020 Dec;62(6):664-672. Epub 2020 Sep 28 doi: 10.1002/mus.27064. PMID: 32929722
Liew WK, Kang PB
Curr Opin Pediatr 2013 Dec;25(6):694-700. doi: 10.1097/MOP.0b013e328365ad16. PMID: 24141560
Papazian O
J Child Neurol 1992 Apr;7(2):135-41. doi: 10.1177/088307389200700202. PMID: 1573230

Therapy

Grover KM, Sripathi N
Muscle Nerve 2020 Dec;62(6):664-672. Epub 2020 Sep 28 doi: 10.1002/mus.27064. PMID: 32929722
Hassan A, Yasawy ZM
Sultan Qaboos Univ Med J 2017 Aug;17(3):e259-e267. Epub 2017 Oct 10 doi: 10.18295/squmj.2017.17.03.002. PMID: 29062547Free PMC Article
Vrinten C, van der Zwaag AM, Weinreich SS, Scholten RJ, Verschuuren JJ
Cochrane Database Syst Rev 2014 Dec 17;2014(12):CD010028. doi: 10.1002/14651858.CD010028.pub2. PMID: 25515947Free PMC Article
Liew WK, Kang PB
Curr Opin Pediatr 2013 Dec;25(6):694-700. doi: 10.1097/MOP.0b013e328365ad16. PMID: 24141560
Barlow CF
Am J Dis Child 1981 Mar;135(3):209. doi: 10.1001/archpedi.1981.02130270001001. PMID: 7211772

Prognosis

Anabusi S, Izenberg A, Barnett C, Berndl A
Muscle Nerve 2024 Mar;69(3):318-324. Epub 2023 Dec 29 doi: 10.1002/mus.28021. PMID: 38156425
Masra F, Ishak S, Cheah FC
Turk J Pediatr 2023;65(2):321-325. doi: 10.24953/turkjped.2022.717. PMID: 37114697
Iijima S
Pediatr Neonatol 2021 Nov;62(6):581-590. Epub 2021 Jun 19 doi: 10.1016/j.pedneo.2021.05.020. PMID: 34272198
Hamel J, Ciafaloni E
Neurol Clin 2018 May;36(2):355-365. doi: 10.1016/j.ncl.2018.01.005. PMID: 29655454
Téllez-Zenteno JF, Hernández-Ronquillo L, Salinas V, Estanol B, da Silva O
BMC Musculoskelet Disord 2004 Nov 16;5:42. doi: 10.1186/1471-2474-5-42. PMID: 15546494Free PMC Article

Clinical prediction guides

Iijima S
Pediatr Neonatol 2021 Nov;62(6):581-590. Epub 2021 Jun 19 doi: 10.1016/j.pedneo.2021.05.020. PMID: 34272198
Kochhar PK, Schumacher RE, Sarkar S
J Perinatol 2021 Sep;41(9):2279-2283. Epub 2021 Feb 17 doi: 10.1038/s41372-021-00970-6. PMID: 33597740
Ducci RD, Lorenzoni PJ, Kay CS, Werneck LC, Scola RH
Neuromuscul Disord 2017 Apr;27(4):352-357. Epub 2017 Feb 1 doi: 10.1016/j.nmd.2017.01.021. PMID: 28256306
Vrinten C, van der Zwaag AM, Weinreich SS, Scholten RJ, Verschuuren JJ
Cochrane Database Syst Rev 2014 Dec 17;2014(12):CD010028. doi: 10.1002/14651858.CD010028.pub2. PMID: 25515947Free PMC Article
Gveric-Ahmetasevic S, Colić A, Elvedji-Gasparović V, Gverić T, Vukelić V
J Perinat Med 2008;36(6):503-6. doi: 10.1515/JPM.2008.070. PMID: 18681836

Recent systematic reviews

Vrinten C, van der Zwaag AM, Weinreich SS, Scholten RJ, Verschuuren JJ
Cochrane Database Syst Rev 2014 Dec 17;2014(12):CD010028. doi: 10.1002/14651858.CD010028.pub2. PMID: 25515947Free PMC Article

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